Eradication of established intracranial rat gliomas by transforming growth factorβ antisense gene therapy

Habib Fakhrai; Oliver Dorigo; Daniel L. Shawler

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Eradication of established intracranial rat gliomas by transforming growth factorβ antisense gene therapy

机译：转化生长因子β反义基因疗法根除已建立的颅内大鼠神经胶质瘤

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Like human gliomas, the rat 9L gliosarcoma secretes the immunosuppressive transforming growth factor β (TGF-β). Using the model, we tested our hypothesis that genetic modification of glioma cells to block TGF-β expression may enhance their immunogenicity and make them more suitable for active tumor immunotherapy.

机译：像人类神经胶质瘤一样，大鼠9L胶质肉瘤也分泌免疫抑制性转化生长因子β（TGF-β）。使用该模型，我们检验了这样的假设，即神经胶质瘤细胞的遗传修饰以阻止TGF-β表达可能增强其免疫原性，并使它们更适合于主动肿瘤免疫疗法。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2909-2914|共6页
作者
Habib Fakhrai; Oliver Dorigo; Daniel L. Shawler;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats [J] . LI Wei-fang, ZHANG Guang-ji, ZHU Cheng, Journal of Medical Colleges of PLA . 2003,第4期

机译：血管内皮生长因子反义寡核苷酸抑制大鼠颅内神经胶质瘤的发生
2. Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats [J] . 李维方, 张光霁, 朱诚, 中国人民解放军军医大学学报（英文版） . 2003,第004期

机译：血管内皮生长因子反义寡核苷酸抑制大鼠颅内神经胶质瘤的发生
3. Antisense extracellular signal-regulated kinase-2 gene therapy inhibits platelet-derived growth factor-induced proliferation, migration and transforming growth factor-beta(1) expression in vascular smooth muscle cells and attenuates transplant vascul [J] . Chen XL, Chen ZS, Ding Z, Transplant international : . 2008,第1期

机译：反义细胞外信号调节激酶2基因疗法抑制血小板衍生的生长因子诱导的血管平滑肌细胞增殖，迁移和转化生长因子β（1）表达，并减弱移植血管
4. Delivery Technology of Growth Factorsto Realize Tissue Regeneration Therapy [C] . Yasuhiko Tabata Asian Biomaterials Congress . 2008

机译：增长因子递送技术实现组织再生治疗
5. The potential role of basic fibroblast growth factor in malignant transformation, angiogenesis, invasion and proliferation of human gliomas. [D] . Gately, Stephen Thomas. 1997

机译：碱性成纤维细胞生长因子在人类神经胶质瘤的恶性转化，血管生成，侵袭和增殖中的潜在作用。
6. Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy. [O] . H Fakhrai, O Dorigo, D L Shawler, 1996

机译：通过转化生长因子β反义基因治疗根除已建立的颅内大鼠神经胶质瘤。
7. Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy. [O] . Fakhrai, H, Dorigo, O, Shawler, D L, 1996

机译：通过转化生长因子β反义基因治疗根除已建立的颅内大鼠神经胶质瘤。

Eradication of established intracranial rat gliomas by transforming growth factorβ antisense gene therapy

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