Microneedle array-based carbon paste amperometric sensors and biosensors

Joshua Ray Windmiller Nandi Zhou Min-Chieh Chuang Gabriela Valdés-Ramírez Padmanabhan Santhosh Philip R. Miller Roger Narayan and Joseph Wang

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Microneedle array-based carbon paste amperometric sensors and biosensors

机译：基于微针阵列的碳糊安培传感器和生物传感器

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The design and characterization of a microneedle array-based carbon paste electrode towardsnminimally invasive electrochemical sensing are described. Arrays consisting of 3 u0002 3 pyramidalnmicroneedle structures, each with an opening of 425 mm, were loaded with a metallized carbon pastentransducer. The renewable nature of carbon paste electrodes enables the convenient packing of hollownnon-planar microneedles with pastes that contain assorted catalysts and biocatalysts. Smoothing thensurface results in good microelectrode-to-microelectrode uniformity. Optical and scanning electronnmicrographs shed useful insights into the surface morphology at the microneedle apertures. Thenattractive performance of the novel microneedle electrode arrays is illustrated in vitro for the lowpotentialndetection of hydrogen peroxide at rhodium-dispersed carbon paste microneedles and fornlactate biosensing by the inclusion of lactate oxidase in the metallized carbon paste matrix. Highlynrepeatable sensing is observed following consecutive cycles of packing/unpacking the carbon paste. Thenoperational stability of the array is demonstrated as well as the interference-free detection of lactate innthe presence of physiologically relevant levels of ascorbic acid, uric acid, and acetaminophen. Uponnaddressing the biofouling effects associated with on-body sensing, the microneedle carbon pastenplatform would be attractive for the subcutaneous electrochemical monitoring of a number ofnphysiologically relevant analytes.

机译：描述了针对微创电化学传感的基于微针阵列的碳糊电极的设计和表征。阵列由3个u0002 3个金字塔形微针结构组成，每个结构的开口为425 mm，装有金属化的碳糊状传感器。碳糊电极的可再生特性使中空非平面微针可以方便地填充含有各种催化剂和生物催化剂的糊状物。然后使表面光滑导致微电极到微电极的良好均匀性。光学和扫描电子显微照片有助于深入了解微针孔处的表面形态。然后在体外说明了用于在铑分散的碳糊微针上过氧化氢的低电位检测和通过在金属化的碳糊基质中包含乳酸氧化酶来抑制生物传感的新型微针电极阵列的诱人性能。在连续的包装/拆开碳浆循环之后，观察到高度不可重复的感测。然后证明了该阵列的操作稳定性，以及在生理相关水平的抗坏血酸，尿酸和对乙酰氨基酚存在下对乳酸的无干扰检测。在解决了与体感相关的生物污染效应后，微针碳糊状平台对于皮下电化学监测许多生理相关的分析物将具有吸引力。

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《The Analyst》 |2011年第9期|p.1846-1851|共6页
作者
Joshua Ray Windmiller Nandi Zhou Min-Chieh Chuang Gabriela Valdés-Ramírez Padmanabhan Santhosh Philip R. Miller Roger Narayan and Joseph Wang;
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aDepartment of NanoEngineering, University of California, San Diego,9500 Gilman Drive, La Jolla, CA, 92093-0448, USA. E-mail:josephwang@ucsd.edu, Fax: +1 858 534-9553, Tel: +1 858 246-0128bJoint Department of Biomedical Engineering, University of NorthCarolina and North Carolina State University, Campus Box 7115,Raleigh, NC, 27695-7115, USA. E-mail: roger_narayan@unc.edu, Fax:+1 509 696-8481, Tel: +1 919 696-8488,;

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1. Microneedle array-based carbon paste amperometric sensors and biosensors [J] . Windmiller J.R., Zhou N., Chuang M.-C., The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2011,第9期

机译：基于微针阵列的碳糊安培传感器和生物传感器
2. Multiwalled Carbon Nanotubes for Amperometric Array-Based Biosensors [J] . Irene Taurino, Giovanni De Micheli, Sandro Carrara BioNanoscience . 2012,第4期

机译：用于基于安培阵列的生物传感器的多壁碳纳米管。
3. Development of amperometric biosensor in modified carbon paste with enzymatic preparation based on lactase immobilized on carbon nanotubes [J] . de Brito Aila Riany, Reis Nadabe dos Santos, Oliveira Polyany Cabral, Journal of Food Science and Technology . 2020,第4期

机译：基于碳纳米管固定在碳纳米管上固定的乳糖酶的改性碳浆料中碳浆料中的化工浆料的发展
4. Chemical Modified Carbon Paste Amperometric Sensor for the Detection ofSilver (I) [C] . Haili Zhang International seminar on electroanalytical chemistry . 2001

机译：化学改性碳浆料的安培传感器用于检测Silver（I）
5. A CMOS switched capacitor based amperometric readout circuit for microneedle glucose sensor. [D] . Govardhan, Sunil. 2013

机译：用于微针葡萄糖传感器的基于CMOS开关电容器的电流表读出电路。
6. Development of amperometric biosensor in modified carbon paste with enzymatic preparation based on lactase immobilized on carbon nanotubes [O] . Aila Riany de Brito, Nadabe dos Santos Reis, Polyany Cabral Oliveira, 2020

机译：基于碳纳米管固定在碳纳米管上固定的乳糖酶的改性碳糊剂的酶碳糊剂的开发
7. A novel amperometric catechol biosensor based on alpha-Fe2O3 nanocrystals-modified carbon paste electrode [O] . Sarika, C, Shivakumar, M S, Shivakumara, C, 2017

机译：基于α-Fe2O3纳米晶体修饰的碳糊电极的新型电流型邻苯二酚生物传感器

Microneedle array-based carbon paste amperometric sensors and biosensors

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