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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Microneedle array-based carbon paste amperometric sensors and biosensors
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Microneedle array-based carbon paste amperometric sensors and biosensors

机译：基于微针阵列的碳糊安培传感器和生物传感器

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摘要

The design and characterization of a microneedle array-based carbon paste electrode towards minimally invasive electrochemical sensing are described. Arrays consisting of 3 × 3 pyramidal microneedle structures, each with an opening of 425 m, were loaded with a metallized carbon paste transducer. The renewable nature of carbon paste electrodes enables the convenient packing of hollow non-planar microneedles with pastes that contain assorted catalysts and biocatalysts. Smoothing the surface results in good microelectrode-to- microelectrode uniformity. Optical and scanning electron micrographs shed useful insights into the surface morphology at the microneedle apertures. The attractive performance of the novel microneedle electrode arrays is illustrated in vitro for the low-potential detection of hydrogen peroxide at rhodium-dispersed carbon paste microneedles and for lactate biosensing by the inclusion of lactate oxidase in the metallized carbon paste matrix. Highly repeatable sensing is observed following consecutive cycles of packing/unpacking the carbon paste. The operational stability of the array is demonstrated as well as the interference-free detection of lactate in the presence of physiologically relevant levels of ascorbic acid, uric acid, and acetaminophen. Upon addressing the biofouling effects associated with on-body sensing, the microneedle carbon paste platform would be attractive for the subcutaneous electrochemical monitoring of a number of physiologically relevant analytes.
机译：描述了针对微创电化学传感的基于微针阵列的碳糊电极的设计和表征。阵列由3×3的金字塔形微针结构组成，每个结构的开口为425 m，并装有金属化的碳糊换能器。碳糊电极的可再生特性使中空非平面微针可以方便地填充含有各种催化剂和生物催化剂的糊状物。使表面光滑使微电极间的均匀性良好。光学和扫描电子显微照片有助于深入了解微针孔处的表面形态。通过在铑分散的碳糊微针上低电位检测过氧化氢，以及通过在金属化碳糊基质中包含乳酸氧化酶来进行乳酸生物传感，在体外说明了新型微针电极阵列的诱人性能。在连续的包装/拆开碳浆循环之后，观察到了高度可重复的感测。证明了该阵列的操作稳定性以及在生理相关水平的抗坏血酸，尿酸和对乙酰氨基酚存在下对乳酸的无干扰检测。在解决了与人体感应相关的生物污染效应后，微针碳糊平台将对多种生理相关分析物的皮下电化学监测具有吸引力。

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