摘要：Aminoglycosides such as gentamicin，streptomycin，kanamycin and tobramycin are clinically important drugs. The use of these drugs can frequently lead to irreversible hearing loss. Aminoglycoside ototoxicity accounts for a significant portion of deafiness. In familial cases of ototoxic deafness，the aminoglycoside hypersensitivity is often matemaUy transmitted，suggesting that the mutation(s)in mitochondrial DNA is the molecular basis of this disorder. Mutational analysis has led to the identification of several ototoxic mutations in mitochondrial 12S rRNA. In particular，the A1555G and C1494T mutations account for significant cases ofaminoglycoside ototoxicity. The A1555G or C 1494T mutation creates the binding sites of the highly conserved Asiteof 12S rRNA and make the secondary structure of this RNA more closely resemble the corresponding region of bacterial 16S rRNA. Thus，these mutations facilitate the binding of aminoglycosides，thereby accounting for the fact that the exposure to aminoglycosides can induce or worsen hearing loss in individuals carrying these mutations.Therefore，these data
摘要：本文对100例人工流产术后患者立即放置GyneFix IN IUD的治疗效果进行了介绍。常规放置宫内节育器的时间为月经干净后3-7天，人工流产后立即放置宫内节育器虽然被认为是安全可行的上环时期，但是因人流后宫颈管松驰，子宫复旧等改变，立即放置传统宫内节育器，易使环位下移，造成脱落和出血等更高，故一般不主张人流后立即放置宫内节育器。第三代活性新型宫内节育器GyneFix IN IUD，克服了以上的缺点，因妊娠率和续用率均优于传统宫内节育器，现己广泛应用于临床，尤其是人工流产后立即放置宫内节育器的最佳选择。
