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首页> 外文期刊>Physiology & behavior >Effects of abuse pattern of gestational toluene exposure on metabolism, feeding and body composition.
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Effects of abuse pattern of gestational toluene exposure on metabolism, feeding and body composition.

机译：妊娠甲苯暴露的滥用方式对代谢，摄食和身体组成的影响。

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AIMS: Inhalant abuse during pregnancy lowers birth weight and impedes early development. These studies explored the effects of brief, repeated, prenatal toluene exposures in pregnant female rats on body weight, metabolic rate, body composition, and food intake in their offspring. METHOD: Rats were exposed to 0, 8000, 12,000, or 16,000 ppm of toluene twice daily for 15 min from gestational days 8 to 20. The effects of such exposures on post-weaning litter weights, oxygen consumption, carbon dioxide output, and body fat content were determined in 2 cohorts (n=23, n=24) of offspring. Food intakes and weight changes in response to 3 different diets (regular chow, purified diet, purified high fat diet) were examined in another cohort (n=24) from postnatal days 72 to 116. RESULTS: Litter weights showed a significant linear decrease as a function of toluene dose. Offspring exposed to the 16,000 ppm toluene dose displayed statistically lower energy expenditures than control rats. Male rats exposed to 8000 or 16,000 ppm toluene had significantly greater percentage of body fat as well as total body fat than the other groups. Toluene also significantly suppressed weight gain over the time chow was consumed compared to the 0 ppm control group. Finally there were trends for a main effect of toluene dose on food intake during chow and during high fat diet consumption, with rats in the 12,000 ppm group consuming more than the 0 ppm group on both diets. DISCUSSION: These data suggest that, in addition to other previously documented abnormalities in neurological development and behavior, the physiological regulation of metabolism and body composition in males as well as food intake and weight gain in both sexes may be altered by prenatal exposure to toluene.
机译：目的：怀孕期间滥用吸入剂可降低出生体重并阻碍早期发育。这些研究探索了怀孕雌性大鼠短暂，反复，产前甲苯暴露对其体重，新陈代谢率，身体组成和其后代食物摄入的影响。方法：从妊娠第8天到20天，大鼠每天两次暴露于0、8000、12,000或16,000 ppm的甲苯中，持续15分钟，每次15分钟。这些暴露对断奶后仔猪体重，耗氧量，二氧化碳排放量和身体的影响在两个后代（n = 23，n = 24）中确定了脂肪含量。在出生后72至116天的另一个队列（n = 24）中，检查了对3种不同饮食（常规饮食，纯饮食，纯高脂肪饮食）的食物摄入量和体重变化。甲苯剂量的函数。暴露于16,000 ppm甲苯剂量的后代在统计学上显示比对照大鼠更低的能量消耗。暴露于8000 ppm或16,000 ppm甲苯的雄性大鼠的体脂和总体脂百分比明显高于其他组。与0 ppm对照组相比，甲苯在消耗食物的时间内也显着抑制了体重增加。最终，在食物摄入和低脂饮食期间，甲苯剂量对食物摄入量有主要影响的趋势，在这两种饮食中，12,000 ppm组的大鼠摄入量均高于0 ppm组。讨论：这些数据表明，除其他先前已记录的神经系统发育和行为异常外，产前暴露于甲苯可能会改变男性的新陈代谢和身体组成的生理调节以及男女的食物摄入和体重增加。

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