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Tyrosinase maturation through the mammalian secretory pathway: bringing color to life

机译:酪氨酸酶通过哺乳动物分泌途径的成熟:赋予生命色彩

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Tyrosinase has been extensively utilized as a model substrate to study the maturation of glycoproteins in the mammalian secretory pathway. The visual nature of its enzymatic activity (melanin production) has facilitated the identification and characterization of the proteins that assist it becoming a functional enzyme, localized to its proper cellular location. Here, we review the steps involved in the maturation of tyrosinase from when it is first synthesized by cytosolic ribosomes until the mature protein reaches its post-Golgi residence in the melanosomes. These steps include protein processing, covalent modifications, chaperone binding, oligomerization, and trafficking. The disruption of any of these steps can lead to a wide range of pigmentation disorders.
机译:酪氨酸酶已被广泛用作模型底物,以研究哺乳动物分泌途径中糖蛋白的成熟。它的酶促活性(黑色素生成)的视觉特性促进了蛋白质的鉴定和表征,这些蛋白质有助于使其成为功能性酶,位于其适当的细胞位置。在这里,我们回顾了酪氨酸酶成熟的步骤,从最初由胞质核糖体合成酪氨酸酶直至成熟蛋白到达其在黑素体中的高尔基体后驻留。这些步骤包括蛋白质加工,共价修饰,分子伴侣结合,低聚和运输。这些步骤中的任何一个步骤的中断都可能导致广泛的色素沉着障碍。

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