Structures of 2-acetylaminofluorene modified DNA revisited: insight into conformational heterogeneity.

Patnaik S; Cho BP

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Structures of 2-acetylaminofluorene modified DNA revisited: insight into conformational heterogeneity.

机译：重新研究2-乙酰氨基芴修饰的DNA的结构：构象异质性的见解。

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Despite the extensive data on dG-AAF, the major DNA adduct derived from the model carcinogen 2-acetylaminofluorene, little is known with respect to its solution structures. Here, we provide NMR/CD evidence for three conformers of dG-AAF in duplex DNA: major groove B-type (B), base-displaced stacked (S), and minor groove wedge (W). The S/B/W-conformational heterogeneities were found to be sensitive to the nature of the flanking DNA sequence contexts and pH.

机译：尽管有关于dG-AAF（衍生自模型致癌物2-乙酰氨基芴）的主要DNA加合物的大量数据，但对其溶液结构了解甚少。在这里，我们提供了dG-AAF在双链体DNA中的三个构象的NMR / CD证据：大沟B型（B），碱基错位堆叠（S）和小沟楔（W）。发现S / B / W构象异质性对侧翼DNA序列背景和pH的性质敏感。

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《Chemical research in toxicology》 |2010年第11期|共3页
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Patnaik S; Cho BP;
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中图分类毒物学（毒理学）;
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1. Structures of 2-acetylaminofluorene modified DNA revisited: insight into conformational heterogeneity. [J] . Patnaik S, Cho BP Chemical research in toxicology . 2010,第11期

机译：重新研究2-乙酰氨基芴修饰的DNA的结构：构象异质性的见解。
2. Revisiting Francisella tularensis subsp. holarctica, Causative Agent of Tularemia in Germany With Bioinformatics: New Insights in Genome Structure, DNA Methylation and Comparative Phylogenetic Analysis [J] . Anne Busch, Prasad Thomas, Eric Zuchantke, Frontiers in Microbiology . 2018,第6期

机译：重新审视<斜视>弗朗西拉Tularensis 子<斜视> Holarctica ，德国造成的造成造成的生物信息学：基因组结构的新见解，DNA甲基化和比较系统发育分析
3. Phylogeography of Asparagopsis taxiformis revisited: Combined mtDNA data provide novel insights into population structure in Japan [J] . Kurihara Akira, Horiguchi Hanna, Hanyuda Takeaki, Phycological Research . 2016,第2期

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4. Manipulation of DNA molecule utilizing the conformational transition in the higher order structure of DNA [C] . Morishima, K., Fukuda, Robotics and Automation, 1997. Proceedings., 1997 IEEE International Conference on . 1997

机译：利用DNA高阶结构中的构象转变来操纵DNA分子
5. Molecular modeling and experimental determination of the structure of C8 -arylguanine modified oligonucleotides that preferentially adopt the Z -DNA conformation. [D] . Heavner, Sue Ellen. 2004

机译：分子建模和实验确定优先采用Z -DNA构象的C8-芳基鸟嘌呤修饰的寡核苷酸的结构。
6. Structures of 2-Acetylaminofluorene Modified DNA Revisited: Insight into Conformational Heterogeneity [O] . Satyakam Patnaik, Bongsup P. Cho -1

机译：2-乙酰氨基芴的结构修饰的DNa重访：洞察构象异构
7. Structures of 2-Acetylaminofluorene Modified DNA Revisited: Insight into Conformational Heterogeneity [O] . Satyakam Patnaik, Bongsup P. Cho 2010

机译：重新讨论了2-乙酰氨基氟烯酮改性DNA的结构：洞察一致性异质性

Structures of 2-acetylaminofluorene modified DNA revisited: insight into conformational heterogeneity.

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