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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Successful postexposure rabies prophylaxis after erroneous starting treatment.
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Successful postexposure rabies prophylaxis after erroneous starting treatment.

机译：错误的开始治疗后，成功的预防狂犬病后狂犬病的预防。

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摘要

BACKGROUND: Postexposure prophylaxis, adequately applied after exposure to a rabid animal, is highly effective in prevention of human disease. Deviations from the recommended vaccination postexposure treatment protocol have been associated with vaccination failure and human mortality. We investigated an incident in which seven Israel Defense Forces soldiers were bitten by a rabid fox and initially treated not in accordance with the recommended vaccination protocol. METHODS: The soldiers received modified anti-rabies postexposure prophylaxis, including a higher dosage of both the active and the passive vaccines. The humoral antibody response was monitored subsequently. RESULTS: All soldiers showed a satisfactory increase (above 0.5 UE/ml by ELISA) in serum anti-rabies antibody titers. None developed the disease more than a year after follow-up. CONCLUSIONS: Strict adherence to the treatment guidelines following an injury by a rabid animal is of utmost importance. We suggest possible compensatory management after a potentially lethal deviation from protocol. Copyright 1999 American Health Foundation and Academic Press.
机译：背景：暴露于狂犬病后充分使用暴露后预防措施，对预防人类疾病非常有效。与建议的疫苗接种后暴露治疗方案的偏离与疫苗接种失败和人类死亡率有关。我们调查了一次事件，其中七名以色列国防军士兵被狂犬病的狐狸咬伤，最初并未按照建议的疫苗接种方案进行治疗。方法：士兵们接受了改良的抗狂犬病暴露后预防，包括较高剂量的主动和被动疫苗。随后监测体液抗体反应。结果：所有士兵的血清抗狂犬病抗体滴度均显示出令人满意的提高（ELISA法高于0.5 UE / ml）。随访一年以上没有人患此病。结论：严格遵守狂犬病动物受伤后的治疗准则至关重要。我们建议在可能致命的偏离协议后进行可能的补偿性管理。版权所有1999美国健康基金会和学术出版社。

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