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Bioactive glass-polymer materials for controlled release of ibuprofen

机译:用于布洛芬控释的生物活性玻璃聚合物材料

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The ibuprofen (1B) release from samples composed by SiO2-CaO-P2O5 bioactive glass, poly-L-lactic acid (PLA), and polymethylmethacrylate (PMMA) has been studied. Data showed a fast anti-inflammatory drug release during the first 8 h when these polyphasic materials are soaked in simulated body fluid (SBF). The analysis of the samples before and after different soaking periods in SBF demonstrates the growth of an apatite-like layer on the materials surface. The 113 release rate is related with the growth kinetics of this layer, that is slower when the materials do not contain the biodegradable polymer PLA. On the other hand, different 113 and/or glass contents do not affect the in vitro behavior of these materials. (C) 2003 Elsevier Science Ltd. All rights reserved. [References: 36]
机译:研究了由SiO2-CaO-P2O5生物活性玻璃,聚L-乳酸(PLA)和聚甲基丙烯酸甲酯(PMMA)组成的样品中布洛芬(1B)的释放。数据显示,将这些多相材料浸泡在模拟体液(SBF)中的最初8小时内,消炎药快速释放。在SBF中不同浸泡时间之前和之后的样品分析表明,材料表面磷灰石样层的生长。 113的释放速率与该层的生长动力学有关,当材料不包含可生物降解的聚合物PLA时,释放速率较慢。另一方面,不同的113和/或玻璃含量不会影响这些材料的体外行为。 (C)2003 Elsevier ScienceLtd。保留所有权利。 [参考:36]

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