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Control of saccadic eye movements and combined eye/head gaze shifts by the medio-posterior cerebellum.

机译:通过中后小脑控制眼跳运动和合并的眼/头视线移动。

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摘要

The cerebellar areas involved in the control of saccades have recently been identified in the medio-posterior cerebellum (MPC). Unit activity recordings, experimental lesions and electrical microstimulation of this region in cats and monkeys have provided a considerable amount of data and allowed the development of new computational models. In this paper, we review these data and concepts about cerebellar function, discuss their importance and limitations and suggest future directions for research. The anatomical data indicate that the MPC has more than one site of action in the visuo-oculomotor system. In contrast, most models emphasize the role of cerebellar connections with immediate pre-oculomotor circuits in the reticular formation, and only one recent model also incorporates the ascending projections of the MPC to the superior colliculus. A major challenge for future studies, in continuation with this initial attempt, is to determine whether the various cerebellar output pathways correspond to distinct contributions to the control of saccadic eye movements. Also, a series of recent studies in the cat have indicated a more general role of the MPC in the control of orienting movements in space, calling for an increasing effort to the study of the MPC in the production of head-unrestrained saccadic gaze shifts.
机译:最近在中后小脑(MPC)中发现了参与扫视运动控制的小脑区域。在猫和猴中该区域的单位活动记录,实验性损伤和电微刺激已经提供了大量数据,并允许开发新的计算模型。在本文中,我们回顾了有关小脑功能的数据和概念,讨论了它们的重要性和局限性,并提出了未来的研究方向。解剖数​​据表明,MPC在视觉动眼系统中具有多个作用部位。相反,大多数模型强调小脑与网状结构眼前动眼前回路的联系,只有最近的一种模型也将MPC的上升投影纳入上丘。继此最初尝试之后,未来研究的一个主要挑战是确定各种小脑输出途径是否对应于控制眼跳运动的独特贡献。同样,最近在猫中进行的一系列研究表明,MPC在控制空间定向运动方面具有更一般的作用,因此需要加大对MPC的研究,以产生头部不受约束的眼跳视线。

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