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首页> 外文期刊>Public Health Nutrition >Effect of combining multiple micronutrients with iron supplementation on Hb response in children: systematic review of randomized controlled trials.
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Effect of combining multiple micronutrients with iron supplementation on Hb response in children: systematic review of randomized controlled trials.

机译：多种微量营养素与铁的补充结合对儿童血红蛋白反应的影响：随机对照试验的系统评价。

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Objectives: To study the effect of combining multiple (two or more) micronutrients with Fe supplementation on Hb response, when compared with placebo and with Fe supplementation, in children. Data sources: Electronic databases, personal files, hand search of reviews, bibliographies of books, and abstracts and proceedings of international conferences. Review methods: Randomized controlled trials evaluating change in Hb levels with interventions that included Fe and multiple-micronutrient supplementation in comparison to placebo alone or Fe alone were analysed in two systematic reviews. Results: Twenty-five trials were included in the review comparing Fe and micronutrient supplementation with placebo. The pooled estimate (random effects model) for change in Hb with Fe and micronutrient supplementation (weighted mean difference) was 0.65 g/dl (95% CI 0.50, 0.80, P<0.001). Lower baseline Hb, lower height-for-age Z score, non-intake of 'other micronutrients' and malarial non-hyperendemic region were significant predictors of greater Hb response and heterogeneity. Thirteen trials were included in the review comparing Fe and micronutrient supplementation with Fe alone. The pooled estimate for change in Hb with Fe and micronutrient supplementation (weighted mean difference) was 0.14 g/dl (95% CI 0.00, 0.28, P=0.04). None of the variables were found to be significant predictors of Hb response. Conclusions: Synthesized evidence indicates that addition of multiple micronutrients to Fe supplementation may only marginally improve Hb response compared with Fe supplementation alone. However, addition of 'other micronutrients' may have a negative effect. Routine addition of unselected multiple micronutrients to Fe therefore appears unjustified for nutritional anaemia control programmes.
机译：目的：研究与安慰剂和补充铁相比，多种（两种或多种）微量营养素与补充铁结合对儿童血红蛋白反应的影响。数据来源：电子数据库，个人文件，对评论的手工搜索，书籍目录，国际会议的摘要和议事录。审查方法：在两项系统评价中，分析了与单独使用安慰剂或单独使用Fe相比，通过干预措施（包括Fe和多种微量营养素补充剂）评估Hb水平变化的随机对照试验。结果：本评价包括25项试验，比较了铁和微量营养素与安慰剂的补充。补充铁和微量营养素（加权平均差）引起的血红蛋白变化的汇总估算值（随机效应模型）为0.65 g / dl（95％CI 0.50，0.80， P <0.001）。较低的基线Hb，较低的年龄高度 Z 得分，不摄入“其他微量营养素”和疟疾的非高血脂区是Hb反应和异质性更高的重要预测指标。本评价包括13个试验，比较了Fe和微量营养素与单独添加Fe的情况。混合添加铁和微量营养素（加权平均差）得出的Hb变化的合并估计值为0.14 g / dl（95％CI 0.00，0.28， P = 0.04）。没有发现任何变量是Hb反应的重要预测因子。结论：综合证据表明，与单独添加铁相比，添加多种微量营养素仅可略微改善Hb反应。但是，添加“其他微量营养素”可能会产生负面影响。因此，将常规非选择的多种微量营养素添加到铁中似乎对营养性贫血控制计划是不合理的。

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