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A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability

机译：避免伤害与脑中烟碱型乙酰胆碱受体利用率之间呈正相关

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Prior research indicates that disturbance of cholinergic neurotransmission reduces anxiety, leading to the hypothesis that people with heightened cholinergic function have a greater tendency toward anxiety-like and/or harm-avoidant behavior. We sought to determine if people with elevated levels of harm avoidance (HA), a dimension of temperament from the Temperament and Character Inventory (TCI), have high α4β2* nicotinic acetylcholine receptor (nAChR) availability. Healthy adults (n=105; 47 non-smokers and 58 smokers) underwent bolus-plus-continuous infusion positron emission tomography (PET) scanning using the radiotracer 2-[18F]fluoro-3-(2(S)azetidinylmethoxy) pyridine (abbreviated as 2-FA). During the uptake period of 2-FA, participants completed the TCI. The central study analysis revealed a significant association between total HA and mean nAChR availability, with higher total HA scores being linked with greater nAChR availability. In examining HA subscales, both 'Fear of Uncertainty' and 'Fatigability' were significant, based on higher levels of these characteristics being associated with greater nAChR availabilities. This study adds to a growing body of knowledge concerning the biological basis of personality and may prove useful in understanding the pathophysiology of psychiatric disorders (such as anxiety disorders) that have similar characteristics to HA. Study findings may indicate that heightened cholinergic neurotransmission is associated with increased anxiety-like traits.
机译：先前的研究表明，胆碱能神经传递受到的干扰会减少焦虑，从而导致以下假设：胆碱能功能增强的人更容易出现焦虑样和/或避免伤害的行为。我们试图确定具有较高避免伤害水平（HA）（气质和性格量表（TCI）的一种气质维度）的人是否具有较高的α4β2*烟碱型乙酰胆碱受体（nAChR）可用性。健康成年人（n = 105; 47位非吸烟者和58位吸烟者）接受了放射性示踪剂2- [18F] fluoro-3-（2（S）氮杂环丁烷基甲氧基）吡啶（大剂量加连续输注正电子发射断层扫描（PET）扫描）（缩写为2-FA）。在2-FA吸收期间，参与者完成了TCI。中央研究分析显示，总HA与平均nAChR可用性之间存在显着关联，总HA评分越高与nAChR可用性越高相关。在检查HA分量表时，“不确定性的恐惧”和“可承受性”均很重要，因为这些特征的较高水平与更大的nAChR可用性相关。这项研究增加了有关人格生物学基础的知识，并可能有助于理解与HA具有相似特征的精神疾病（例如焦虑症）的病理生理学。研究结果可能表明胆碱能神经传递增强与焦虑样特征增加有关。

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