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首页> 外文期刊>Psychiatry Research. Neuroimaging >Longitudinal changes in brain structure following the first episode of psychosis
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Longitudinal changes in brain structure following the first episode of psychosis

机译：第一次精神病发作后脑结构的纵向变化

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Both schizophrenia and bipolar disorder have been associated with progressive changes in grey matter (GM) volume. However, the temporal trajectories of these changes are poorly understood. The aim of this study was to assess longitudinal changes in grey matter volume subsequent to the first episode of schizophrenia and of affective psychoses. Adolescent patients with a first episode psychosis (n = 26) were scanned twice using magnetic resonance imaging, at first presentation and after a 3-year follow-up period. An age-matched group of healthy volunteers (n = 17) was scanned at the same time points. Within-group and between-group changes in regional grey matter volume were examined using voxel-based morphometry. There were significant group by time interactions (P_(fdrcoit)<0.05) in the frontal, temporal, parietal, cerebellar cortex, and in the thalamus, mainly reflecting longitudinal reductions in the controls but not in the patients. Subdivision of the patient group revealed that there were similar longitudinal reductions in patients with affective psychoses as in the controls but no volumetric changes in patients with schizophrenia. Psychosis with onset in adolescence or early adulthood may be associated with a delay or a loss of longitudinal reductions in regional grey matter volume that normally occur at this stage of development. These changes may be specific to schizophrenia.
机译：精神分裂症和躁郁症都与灰质（GM）体积的进行性改变有关。但是，这些变化的时间轨迹知之甚少。这项研究的目的是评估精神分裂症和情感性精神病首发后灰质体积的纵向变化。首次出现精神病的青春期患者（n = 26）在首次出现时以及在3年的随访期后均使用磁共振成像扫描了两次。在同一时间点扫描年龄匹配的健康志愿者组（n = 17）。使用基于体素的形态计量学检查区域灰质体积的组内和组间变化。在额叶，颞叶，顶叶，小脑皮质和丘脑中存在显着的按时间的交互作用（P_（fdrcoit）<0.05），主要反映了对照的纵向减少，但患者没有。患者组的细分显示，情感性精神病患者的纵向减少幅度与对照组相似，但精神分裂症患者的体积没有变化。青春期或成年初期发作的精神病可能与延迟或丧失区域灰质体积的纵向减少有关，而这种减少通常发生在发展的这一阶段。这些变化可能是精神分裂症所特有的。

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