...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?
【24h】

Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?

机译：哮喘儿童对社会心理压力的皮质醇反应迟钝：特应性疾病的一般特征？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Atopy is defined by the individual predisposition to develop a group of inflammatory disorders in response to certain food or environmental substances that are otherwise innocuous for the host. In previous studies we could demonstrate a reduced responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to psychosocial stress in young and adult patients with atopic dermatitis (AD), a chronic atopic skin disorder. With respect to the important immunoregulatory role of the HPA axis, especially under stress, this observation could be of clinical relevance and may at least partly explain stress-induced exacerbation of AD. The present study was designed to investigate whether attenuated responsiveness of the HPA axis to stress represents a characteristic feature of AD or whether it can also be found in other chronic manifestations of atopy. METHODS: Children (aged 7-12) with allergic asthma (AA; N = 17) and age- and sex-matched healthy controls (N = 18) were exposed to the "Trier Social Stress Test for Children"(TSST-C), which mainly consists of a free speech and mental arithmetic tasks in front of an audience. Salivary cortisol was measured in ten-minute intervals before and after the TSST-C, while heart rate was monitored continuously. In addition, early morning cortisol levels (after awakening, +10, +20, +30 minutes) were assessed on three consecutive days. RESULTS: Data analysis yielded a significant increase of cortisol concentrations (F (9297)= 16.79; p <.001) and heart rates (F(32,992)= 9.16; p <.001) after the stressor with no between-group difference in heart rate responses. However, AA children showed a significantly blunted cortisol response to the TSST-C when compared with the control group (F(9297)= 2.95; p <.01). Awakening in the morning was accompanied by a significant rise of cortisol levels on all three experimental days in AA and control subjects (all p <.001) that was not different between the two groups. CONCLUSIONS: These findings suggest that a blunted adrenocortical response to stress may represent a common feature of chronic allergic inflammatory processes that may be relevant in different forms of chronic manifestation of atopy.
机译：目的：特应性是由个体易感性定义的，这些易感性是对某些食物或环境物质产生的一组炎症性疾病，这些物质原本对宿主无害。在先前的研究中，我们可以证明患有特应性皮炎（AD）（一种慢性特应性皮肤病）的年轻和成年患者下丘脑-垂体-肾上腺（HPA）轴对社会心理压力的反应性降低。关于HPA轴的重要免疫调节作用，尤其是在压力下，该观察结果可能具有临床意义，并且至少可以部分解释压力引起的AD恶化。本研究旨在调查HPA轴对压力的减弱反应性是否代表AD的特征，或者是否也可以在特应性的其他慢性表现中发现它。方法：对患有过敏性哮喘（AA; N = 17）以及与年龄和性别相匹配的健康对照组（N = 18）的儿童（7-12岁）进行“儿童Trier社会压力测试”（TSST-C） ，主要由听众面前的言论自由和心算任务组成。在TSST-C前后每隔十分钟测量一次唾液皮质醇，同时连续监测心率。此外，连续三天评估清晨皮质醇水平（醒后+ 10，+ 20，+ 30分钟）。结果：数据分析显示，压力源后皮质醇浓度（F（9297）= 16.79; p <.001）和心率（F（32,992）= 9.16; p <.001）显着增加，两组之间无组间差异心率反应。然而，与对照组相比，AA儿童对TSST-C的皮质醇反应明显减弱（F（9297）= 2.95; p <.01）。在AA和对照受试者的所有三个实验日中，早晨的清醒伴随着皮质醇水平的显着升高（所有p <.001），两组之间没有差异。结论：这些发现表明对压力的减弱的肾上腺皮质反应可能代表了慢性过敏性炎症过程的共同特征，这可能与特应性慢性表现的不同形式有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号