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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Hypothalamic blood flow correlates positively with stress-induced cortisol levels in subjects with social anxiety disorder.
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Hypothalamic blood flow correlates positively with stress-induced cortisol levels in subjects with social anxiety disorder.

机译：在患有社交焦虑症的受试者中，下丘脑血流量与应激诱导的皮质醇水平呈正相关。

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OBJECTIVE: The adrenal excretion of cortisol in animals is dependent on the production of corticotropin-releasing factor in the paraventricular nucleus of the hypothalamus. The a priori hypothesis of this study was that hypothalamic regional cerebral blood flow (rCBF) would correlate positively with salivary cortisol levels in patients with social anxiety disorder (SAD) during anxiety provocation. Another objective was to evaluate whether salivary cortisol levels correlated with rCBF in other brain areas. METHOD: Regional CBF was measured with oxygen-15-labeled water and positron emission tomography during a public speaking task before and after placebo treatment in 12 subjects with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-defined SAD. Cortisol concentrations in saliva were measured 15 minutes after the task. The a priori hypothesis of a salivary cortisol-dependent activation of the hypothalamus was studied with region-of-interest analysis. In addition, the covariation between rCBF and salivary cortisol was studied in the whole brain using the general linear model. RESULTS: The region-of-interest analysis revealed a positive correlation between salivary cortisol and hypothalamic rCBF. In the whole brain analysis, a positive covariation between rCBF and salivary cortisol levels was found in a midbrain cluster encompassing the hypothalamus with its statistical maximum in the mamillary bodies. Negative covariations were observed in the medial prefrontal cortex as well as in the motor and premotor cortices. CONCLUSION: Like in animals, stress-induced cortisol excretion in humans may be inhibited by activity in the medial prefrontal cortex and enhanced by activity in the hypothalamus.
机译：目的：动物皮质醇的肾上腺排泄取决于下丘脑室旁核中促肾上腺皮质激素释放因子的产生。这项研究的先验假设是，在社交焦虑症（SAD）患者中，下丘脑局部脑血流量（rCBF）与唾液皮质醇水平呈正相关，在焦虑激发期间。另一个目的是评估唾液皮质醇水平是否与其他脑区域的rCBF相关。方法：用第四版定义的SAD《精神障碍诊断和统计手册》对12名受试者进行安慰剂治疗前后的公开演讲期间，用氧15标记的水和正电子发射断层扫描术测量区域CBF。任务后15分钟测量唾液中的皮质醇浓度。下丘脑唾液皮质醇依赖性激活的先验假设通过感兴趣区域分析进行了研究。此外，使用通用线性模型研究了全脑rCBF与唾液皮质醇的协方差。结果：感兴趣区域分析显示唾液皮质醇与下丘脑rCBF之间呈正相关。在全脑分析中，在包含下丘脑的中脑簇中，rCBF与唾液皮质醇水平之间存在正协变关系，在乳头体中其统计最大值。在内侧前额叶皮层以及运动和运动前皮层中观察到负协变。结论：像动物一样，应激诱导的人类皮质醇排泄可能受到内侧额前皮层活动的抑制，并受到下丘脑活动的增强。

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