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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Psychiatric morbidity and toxic burden in patients with environmental illness: a controlled study.
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Psychiatric morbidity and toxic burden in patients with environmental illness: a controlled study.

机译：环境疾病患者的精神疾病发病率和毒性负担：一项对照研究。

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OBJECTIVE: Patients with environmental illness experience a large number of psychological symptoms. The nature of these symptoms and their pathogenesis (toxicogenic versus psychogenic) is controversial. The objective was to (1) characterize the nature of the psychological symptoms according to well-established diagnostic criteria, and (2) to investigate the association between toxicological factors and psychological symptoms. METHODS: Toxic burden, somatic morbidity, and psychiatric morbidity were assessed in 309 outpatients with environmental illness and 59 semiconductor industry workers matched for age and gender. Psychiatric disorders were assessed by a structured psychiatric interview (SCID), and distress was assessed by the Symptom-Checklist-90-Revised (SCL-90-R). Routine and specific laboratory tests in blood and urine samples were used to assess chemical exposures. RESULTS: Overall psychiatric morbidity was significantly higher in patients than in controls according to SCID (75% versus 24%). Somatoform, mood, and anxiety disorders were significantly more frequent in patients with environmental illness. They also revealed marked stress on the SCL-90-R somatization subscale and scored significantly higher than controls on most of the other subscales. Industry workers from the control group tended to have higher urine metal concentrations than environmental illness patients and similar concentrations of solvents in blood. CONCLUSION: Our data extend previous findings of high psychiatric morbidity in patients with environmental illness. They do not support the notion of a direct causal link between chemical exposure and the psychological symptoms.
机译：目的：患有环境疾病的患者会出现大量的心理症状。这些症状的性质及其发病机理（毒源性与心理性）是有争议的。目的是（1）根据公认的诊断标准表征心理症状的性质，以及（2）研究毒理学因素与心理症状之间的关联。方法：对309名患有环境疾病的门诊患者和59名年龄和性别相匹配的半导体行业工人进行了毒性负荷，躯体发病率和精神疾病发病率评估。精神疾病通过结构化精神病学访谈（SCID）进行评估，而苦恼则通过Symptom-Checklist-90-Revised（SCL-90-R）进行评估。在血液和尿液样本中进行常规和特定的实验室测试来评估化学暴露。结果：根据SCID，患者的整体精神病发病率显着高于对照组（75％比24％）。在患有环境疾病的患者中，躯体形式，情绪和焦虑症的发生率明显更高。他们还揭示了SCL-90-R躯体化分量表上的明显压力，并且在大多数其他分量表上的得分明显高于对照组。对照组的行业工人往往比环境疾病患者的尿液金属浓度更高，并且血液中的溶剂浓度相似。结论：我们的数据扩展了先前对环境疾病患者高精神病发病率的发现。他们不支持化学暴露与心理症状之间存在直接因果关系的观点。

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