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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Effect of depressive symptoms on survival after heart transplantation.
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Effect of depressive symptoms on survival after heart transplantation.

机译：抑郁症状对心脏移植后生存的影响。

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OBJECTIVE: This study explored the value of preoperative self-reported assessment for depression and anxiety in patients who had undergone heart transplantation (HTx). The initial sample was divided into subgroups of patients with ischemic (ICMP) and dilated cardiomyopathy (DCMP). Patient depression and anxiety scores were measured in both subgroups and their impact on pre- and postoperative mortality investigated. METHOD: An initial sample of 152 patients with either ICMP (N = 57) or DCMP (N = 95) and end-stage heart disease awaiting heart transplantation were assessed in a multidimensional longitudinal study, including psychological and somatic variables. One hundred and three patients received a HTx and were followed up for a mean of 4.4 years. Proportional hazard models were computed to test for the influence of psychosocial and somatic factors on outcome. RESULTS: Preoperative depression and state anxiety scores were significantly higher in the ICMP group. In addition to donor and recipient age, ICMP patients in the preoperative high depression group also showed a significantly higher mortality after HTx. This result remained significant even after controlling for sociodemographic and somatic variables. CONCLUSIONS: Patient self-reported depression, but not anxiety, can contribute to the identification of subgroups of patients with an unfavorable outcome after HTx. It therefore may be helpful to screen for depression, particularly in patients with an ischemic cause of their end-stage heart disease. Specific intervention programs should be further developed and evaluated.
机译：目的：本研究探讨了术前自我报告评估对接受心脏移植（HTx）的患者的抑郁和焦虑的价值。初始样本分为缺血性（ICMP）和扩张型心肌病（DCMP）患者亚组。在两个亚组中均测量了患者的抑郁和焦虑评分，并研究了其对术前和术后死亡率的影响。方法：在多维纵向研究中评估了152例ICMP（N = 57）或DCMP（N = 95）且终末期心脏病等待心脏移植的患者的初始样本，包括心理和躯体变量。 103例患者接受了HTx治疗，平均随访4.4年。计算比例风险模型以测试心理社会因素和躯体因素对预后的影响。结果：ICMP组术前抑郁和状态焦虑评分明显高于对照组。除供体和接受者的年龄外，术前高抑郁症组的ICMP患者在HTx术后的死亡率也显着提高。即使在控制了社会人口统计学和躯体变量之后，该结果仍然很显着。结论：患者自我报告的抑郁症（而不是焦虑症）可有助于确定HTx术后不良结局的患者亚组。因此，对抑郁症的筛查可能会有所帮助，尤其是对于患有终末期心脏病的缺血性原因的患者。具体的干预计划应进一步制定和评估。

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