Synthesis of 2-arylacrylates from pyruvate by tosylhydrazide-promoted Pd-catalyzed coupling with aryl halides

Barluenga J.; Tomás-Gamasa M.; Aznar F.; Valdés C.

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Synthesis of 2-arylacrylates from pyruvate by tosylhydrazide-promoted Pd-catalyzed coupling with aryl halides

机译：甲苯磺酰肼促进的Pd与芳基卤化物偶合，由丙酮酸合成2-芳基丙烯酸酯

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摘要

Important synthetic intermediates and direct precursors of the prophen class of anti-inflammatory agents, 2-arylacrylates are prepared in one step from ethyl pyruvate by employing the recently developed Pd-catalyzed cross-coupling between tosylhydrazones and aryl halides. Moreover, substituted 2-oxoesters afford tri- and tetrasubstituted functionalized alkenes.

机译：重要的合成中间体和芬太尼类消炎剂的直接前体，是通过使用最近开发的甲苯磺酰hydr与芳基卤化物之间的钯催化交叉偶联反应，从丙酮酸乙酯一步制备2-芳基丙烯酸酯。此外，取代的2-氧酸酯提供了三和四取代的官能化的烯烃。

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《Chemistry: A European journal》 |2010年第43期|共3页
作者
Barluenga J.; Tomás-Gamasa M.; Aznar F.; Valdés C.;
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原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
arylacrylates; cross-coupling; hydrazones; palladium; pyruvate;

机译：芳基丙烯酸酯;交叉偶联;hydr;钯;丙酮酸盐;

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1. Synthesis of 2-arylacrylates from pyruvate by tosylhydrazide-promoted Pd-catalyzed coupling with aryl halides [J] . Barluenga J., Tomás-Gamasa M., Aznar F., Chemistry: A European journal . 2010,第43期

机译：甲苯磺酰肼促进的Pd与芳基卤化物偶合，由丙酮酸合成2-芳基丙烯酸酯
2. One-pot synthesis of symmetrical and unsymmetrical aryl sulfides by Pd-catalyzed couplings of aryl halides and thioacetates [J] . Park N., Park K., Jang M., The Journal of Organic Chemistry . 2011,第11期

机译：钯催化芳基卤化物和硫代乙酸酯的偶联反应一锅合成对称和不对称芳基硫化物
3. VIPSynthesis of Enol Ethers and Enamines by Pd-Catalyzed Tosylhydrazide-Promoted Cross-Coupling Reactions [J] . Jose Barluenga, Maria Escribano, Patricia Moriel, Chemistry: A European journal . 2009,第48期

机译：Pd催化甲苯磺酰肼促进的交叉偶联反应的VIP合成烯醇醚和烯胺
4. Catalytic Reactions of Ionic Liquids as Substrates: Pd-Catalyzed Coupling Reaction of Imidazolium-Based Ionic Liquids with Aryl Halides [C] . Takahide Fukuyama, Taifur Rahman, Hideo Takahashi Symposium on Organometallic Chemistry . 2007

机译：离子液体作为底物的催化反应：咪唑鎓基离子液体与芳基卤化物的PD催化偶联反应
5. Part I: Microwave-Assisted Continuous Flow Organic Synthesis (MACOS) and the Heck-type aminocarbonylation of aryl halides, and, the Suzuki-Miyaura cross-coupling of chloroformates. Part II: Structure-activity relationship (SAR) analysis of NHC-palladium PEPPSI complexes in aminations and cross-couplings [D] . Nasielski, Joanna 2009

机译：第一部分：微波辅助连续流动有机合成（MACOS）和芳基卤化物的Heck型氨基羰基化，以及氯甲酸酯的Suzuki-Miyaura交叉偶联。第二部分：胺和交叉偶联中NHC-钯PEPPSI复合物的结构-活性关系（SAR）分析
6. tBu3P-Coordinated 2-Phenylaniline-Based Palladacycle Complex As Precatalyst for Pd-Catalyzed Coupling Reactions of Aryl Halides with Polyfluoroarenes via C-H Activation Strategy [O] . Hong-Hai Zhang, Jie Dong, Qiao-Sheng Hu -1

机译：tBu3P配位的2-苯基苯胺基Palladacycle配合物作为C-H活化策略Pd催化卤代芳烃与多氟芳烃偶联反应的前催化剂
7. Ligand-free Pd-Catalyzed C—N Coupling of Diphenylamine and Aryl Halides under Air [O] . Binbin Zhang, Dan Zhan, Xiaoping Zhang, 2012

机译：在空气下的双苯胺和芳基卤化物的无配体PD催化的C-N偶联

Synthesis of 2-arylacrylates from pyruvate by tosylhydrazide-promoted Pd-catalyzed coupling with aryl halides

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