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首页> 外文期刊>The American Journal of the Medical Sciences >The effect of somatostatin, ulinastatin and salvia miltiorrhiza on severe acute pancreatitis treatment
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The effect of somatostatin, ulinastatin and salvia miltiorrhiza on severe acute pancreatitis treatment

机译：生长抑素，乌司他丁和丹参对重症急性胰腺炎的治疗作用

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Background: The aim of this study was to evaluate the efficacy of somatostatin, ulinastatin and Salvia miltiorrhiza for treatment of severe acute pancreatitis. METHODS:: Three hundred six patients with severe acute pancreatitis were divided randomly into 5 groups: basic treatment, somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza. Amount of time for resolution of abdominal pain/distention, recovery to normal heart and respiratory rates, amylase and blood glucose levels, Acute Physiology and Chronic Health Evaluation II scores, and levels of tumor necrosis factor-α, interleukin (IL)-6, and IL-10 were analyzed and recorded for all 5 subgroups. RESULTS:: Tumor necrosis factor-α and IL-6 levels on the fourth and seventh days, and Acute Physiology and Chronic Health Evaluation II scores on the seventh day after treatment showed significant decrease in the somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup. IL-10 levels on the fourth and seventh days were significantly improved in the somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup. The incidences of pancreatic sepsis, multiple organ dysfunction syndrome and mortality were lower in the somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup. CONCLUSIONS:: Somatostatin is effective for the treatment of acute pancreatitis and both ulinastatin and S miltiorrhiza demonstrate improvement in therapeutic benefits.
机译：背景：本研究的目的是评估生长抑素，乌司他丁和丹参治疗严重急性胰腺炎的疗效。方法：将366例重症急性胰腺炎患者随机分为5组：基本治疗，生长抑素，生长抑素+乌司他丁，生长抑素+沙司和生长抑素+乌司他汀+沙司。解决腹部疼痛/不适，恢复正常心脏和呼吸频率，淀粉酶和血糖水平，急性生理和慢性健康评估II得分以及肿瘤坏死因子-α，白介素（IL）-6，分析并记录了所有5个亚组的IL-10和IL-10。结果：在治疗后的第四天和第七天，肿瘤坏死因子-α和IL-6水平以及治疗后第七天的急性生理和慢性健康评估II评分显示，生长抑素，生长抑素+乌司他丁，生长抑素+ S乳清明显降低。与生长激素抑制素+乌拉司他汀+乳香S亚组相比，基本治疗亚组。与基本治疗亚组相比，生长抑素+乌司他丁，生长抑素+乳木果和生长抑素+乌司他丁+乳木果的第4天和第7天IL-10水平显着提高。与基本治疗组相比，生长抑素，生长抑素+乌司他丁，生长抑素+ S溢泻和生长抑素+乌司他丁+ S溢泻组的胰腺败血症，多器官功能不全综合征和死亡率较低。结论：生长抑素可有效治疗急性胰腺炎，乌司他丁和乳香均能改善治疗效果。

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