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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Mycobacterium leprae DNA Associated with Type 1 Reactions in Single Lesion Paucibacillary Leprosy Treated with Single Dose Rifampin, Ofloxacin, and Minocycline.
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Mycobacterium leprae DNA Associated with Type 1 Reactions in Single Lesion Paucibacillary Leprosy Treated with Single Dose Rifampin, Ofloxacin, and Minocycline.

机译：单剂量利福平，氧氟沙星和米诺环素治疗单发病灶性脓疱性麻风病中与1型反应相关的麻风分枝杆菌DNA。

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摘要

Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities. Single skin lesion paucibacillary leprosy volunteers (N = 135) recruited in three Brazilian endemic regions, treated with single-dose rifampin, ofloxacin, and minocycline (ROM), were monitored for 3 years. Poor outcome was defined as type 1 reactions with or without neuritis. IgM anti-phenolic glycolipid I, histopathology, Mitsuda test, and Mycobacterium leprae DNA polymerase chain reaction (ML-PCR) were performed at baseline. chi(2) test, Kaplan-Meir curves, and Cox proportional hazards were applied. The majority of volunteers were adults with a mean age of 30.5 +/- 15.4 years; 44.4% were ML-PCR positive. During follow-up, 14.8% of the patients had a poor clinical outcome, classified as a type 1 reaction. Older age (>/=40 years), ML-PCR positivity, and lesion size > 5cm were associated with increased risk. In multivariate analysis, age (>/=40 years) and ML-PCR positivity remained baseline predictors of type 1 reaction among monolesion leprosy patients.
机译：麻风病会影响皮肤和周围神经，急性1型炎症反应（逆转反应）会导致神经功能障碍和残疾。监测了巴西三个地方病地区招募的单皮肤病灶性脓疱性麻风病志愿者（N = 135），并用单剂量利福平，氧氟沙星和米诺环素（ROM）治疗，为期3年。结果差定义为伴或不伴神经炎的1型反应。在基线进行IgM抗酚糖脂I，组织病理学，Mitsuda试验和麻风分枝杆菌DNA聚合酶链反应（ML-PCR）。应用chi（2）测试，Kaplan-Meir曲线和Cox比例风险。大多数志愿者是成年人，平均年龄为30.5 +/- 15.4岁; ML-PCR阳性的占44.4％。在随访期间，有14.8％的患者临床预后较差，被归为1型反应。年龄较大（> / = 40岁），ML-PCR阳性和病灶尺寸> 5cm与风险增加相关。在多变量分析中，年龄（> / = 40岁）和ML-PCR阳性仍然是单灶性麻风病患者1型反应的基线指标。

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