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首页> 外文期刊>The British journal of psychiatry : >Metabolic profile of antipsychotic-naive individuals with non-affective psychosis.
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Metabolic profile of antipsychotic-naive individuals with non-affective psychosis.

机译：初次使用非情感性精神病的抗精神病药物个体的代谢谱。

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BACKGROUND: Some studies suggest individuals with schizophrenia have an increased risk of diabetes prior to antipsychotic use. Small sample sizes and the potential for confounding by hypercortisolaemia have decreased confidence in those results. AIMS: To examine diabetes-related factors in newly diagnosed, antipsychotic-naive people with non-affective psychosis. METHOD: Participants with psychosis (the psychosis group; n = 50) and matched controls (the control group; n = 50) were given a 2 h oral glucose tolerance test. Fasting concentrations were also determined for adiponectin, interleukin-6 and C-reactive protein. RESULTS: Compared with the control group, the psychosis group had significant increases in 2 h glucose and interleukin-6 concentrations, and in the prevalence of abnormal glucose tolerance (16% of psychosis group v. 0% of control group). Adiponectin and C-reactive protein concentrations did not differ significantly between the two groups. These findings could not be attributed to differences in cortisol concentrations, smoking, gender, neighbourhood of residence, body mass index, aerobic conditioning, ethnicity, socioeconomic status or age. CONCLUSIONS: Individuals with non-affective psychosis appear to have an increased prevalence of abnormal glucose tolerance prior to antipsychotic treatment, as well as abnormalities in a related inflammatory molecule. These underlying problems may contribute to the metabolic side-effects of antipsychotic medications.
机译：背景：一些研究表明，精神分裂症患者在使用抗精神病药之前患糖尿病的风险增加。小样本量和高皮质醇血症混淆的可能性降低了对这些结果的信心。目的：研究初诊断为抗情感病的非情感性精神病患者的糖尿病相关因素。方法：对患有精神病（精神病组; n = 50）和相匹配的对照组（对照组; n = 50）的参与者进行2小时口服葡萄糖耐量测试。还测定了脂联素，白介素6和C反应蛋白的空腹浓度。结果：与对照组相比，精神病组的2 h血糖和白细胞介素6浓度显着升高，并且糖耐量异常的发生率显着升高（精神病组为16％，对照组为0％）。两组之间的脂联素和C反应蛋白浓度无明显差异。这些发现不能归因于皮质醇浓度，吸烟，性别，居住地，体重指数，有氧条件，种族，社会经济地位或年龄的差异。结论：非情感性精神病患者在接受抗精神病药物治疗之前，其糖耐量异常的患病率以及相关炎症分子异常的患病率均升高。这些潜在的问题可能会导致抗精神病药物的代谢副作用。

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