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首页> 外文期刊>The British journal of psychiatry : >Childhood cognitive function and adult psychopathology: Associations with psychotic and non-psychotic symptoms in the general population
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Childhood cognitive function and adult psychopathology: Associations with psychotic and non-psychotic symptoms in the general population

机译：儿童的认知功能和成人心理病理学：与一般人群中的精神病和非精神病症状相关

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Background: Lower cognitive ability in childhood is associated with increased risk of future schizophrenia, but its relationship with adult psychotic-like experiences and other psychopathology is less understood. Aims: To investigate whether this childhood risk factor is shared with adult subclinical psychiatric phenotypes including psychotic-like experiences and general psychiatric morbidity. Method: A population-based sample of participants born in Great Britain during 1 week in March 1946 was contacted up to 20 times between ages 6 weeks and 53 years. Cognition was assessed at ages 8, 11 and 15 years using a composite of age-appropriate verbal and non-verbal cognitive tests. At age 53 years, psychotic-like experiences were self-reported by 2918 participants using four items from the Psychosis Screening Questionnaire and general psychiatric morbidity was assessed using the scaled version of the General Health Questionnaire (GHQ-28). Results: Psychotic-like experiences were reported by 22% of participants, and were highly comorbid with other psychopathology. Their presence in adults was significantly associated with poorer childhood cognitive test scores at ages 8 and 15 years, and marginally so at age 11 years. In contrast, high GHQ scores were not associated with poorer childhood cognition after adjustment for the presence of psychotic-like experiences. Conclusions: Psychotic and non-psychotic psychopathologic symptoms are highly comorbid in the general population. Lower childhood cognitive ability is a risk factor for psychotic-like experiences in mid-life; these phenomena may be one end of a continuum of phenotypic expression driven by variation in early neurodevelopment.
机译：背景：儿童时期较低的认知能力与未来精神分裂症的风险增加有关，但人们对它与成人精神病样经历和其他精神病理学的关系的了解较少。目的：调查这种儿童期危险因素是否与成人亚临床精神病学表型共有，包括精神病样经历和一般精神病学发病率。方法：在1946年3月的1周内于英国出生的参与者进行了人口抽样调查，年龄在6周至53岁之间的联系多达20次。使用适合年龄的口头和非口头认知测验的综合评估年龄在8、11和15岁。在53岁时，有2918名参与者使用“精神病筛查问卷”中的四项内容自我报告了类似精神病的经历，并使用“一般健康问卷”（GHQ-28）的定标版评估了一般精神病的发病率。结果：22％的参与者报告了类似精神病的经历，并且与其他心理病理学高度并存。它们在成人中的存在与8岁和15岁时较差的儿童认知测验得分显着相关，在11岁时与儿童的认知测验得分较弱相关。相比之下，在对类似精神病患者的经历进行调整后，高GHQ分数与较差的儿童认知能力无关。结论：精神病和非精神病的精神病理症状在普通人群中高度合并。儿童期认知能力低下是中年人精神病发作的危险因素。这些现象可能是由早期神经发育变化驱动的表型表达连续体的一端。

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