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首页> 外文期刊>The European Journal of Neuroscience >Glutamate receptor binding in the frontal cortex and dorsal striatum of aged rats with impaired attentional set-shifting.
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Glutamate receptor binding in the frontal cortex and dorsal striatum of aged rats with impaired attentional set-shifting.

机译：谷氨酸受体结合在老年大鼠额叶皮层和背侧纹状体中的注意力定移受损。

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Aged Long-Evans rats exhibit deficits in attentional set shifting, an aspect of executive function, relative to adult rats. Impairments in set shifting and spatial learning are uncorrelated in aged rats, indicating a possible dissociation of the effects of ageing in prefrontal versus hippocampal systems. Ionotropic glutamate receptor binding was assessed using an in vitro autoradiography method in young and aged rats. The rats had been tested on a set-shifting task that measured attentional set shifts and reversal learning, as well as in a spatial learning task in the Morris water maze. [3H]Kainate, [3H]AMPA and NMDA-displaceable [3H]glutamate receptor binding were quantified in orbital cortex, cingulate cortex, medial frontal cortex, dorsolateral and dorsomedial striatum. Age-related decreases in [3H]kainate binding were apparent in all regions measured. Similarly, NMDA-displaceable [3H]glutamate binding was decreased in the aged rats in all the regions measured except for the medial frontal area where no age effects were observed. [3H]AMPA receptor binding was preserved with age in all the regions measured. Lower levels of [3H]kainate binding in the cingulate cortex were significantly correlated with poorer set-shifting performance, whereas higher levels of NMDA binding in the dorsomedial striatum were correlated with poorer set-shifting performance. There were no significant correlations between the levels of ionotropic glutamate receptors and performance in the reversal task or spatial learning in the Morris water maze. These results indicate that age-related behavioural deficits in attentional set shifting are selectively associated with neurobiological alterations in the cingulate cortex and dorsomedial striatum.
机译：相对于成年大鼠，成年的Long-Evans大鼠表现出注意力集中转移不足，这是执行功能的一个方面。老年大鼠的定格移位和空间学习障碍不相关，表明前额叶和海马系统中衰老的影响可能分离。使用体外放射自显影方法在年轻和老年大鼠中评估离子型谷氨酸受体的结合。对大鼠进行了设定转移任务的测试，该任务可测量注意力设定转移和逆向学习，以及在莫里斯水迷宫中进行的空间学习任务。 [3H] Kainate，[3H] AMPA和可移动NMDA的[3H]谷氨酸受体结合在眶皮层，扣带回皮层，内侧额叶皮层，背外侧和背侧纹状体中定量。在所有测量的区域中，与年龄相关的[3H]海藻酸酯结合减少明显。类似地，在测量的所有区域中，除未观察到年龄影响的内侧额叶区域外，在所有测量区域中，NMDA可置换的[3H]谷氨酸结合均降低。在所有测量区域中，[3H] AMPA受体的结合随着年龄的增长而得以保留。扣带回皮层中较低水平的[3H]海藻酸酯结合与较差的移位能力显着相关，而背面纹状体中较高水平的NMDA结合与较差的移位能力有关。在莫里斯水迷宫中逆向任务或空间学习中，离子型谷氨酸受体的水平与性能之间无显着相关性。这些结果表明，注意力集中转移中与年龄相关的行为缺陷与扣带状皮层和背侧纹状体中的神经生物学变化有选择性地相关。

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