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首页> 外文期刊>The European Journal of Neuroscience >Medial prefrontal cortical integration of psychological stress in rats.
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Medial prefrontal cortical integration of psychological stress in rats.

机译：大鼠心理应激的内侧前额叶皮质整合。

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The present study aimed to determine whether the medial prefrontal cortex (mPFC) (prelimbic and infralimbic regions) is implicated in the integration of a stress response. Sprague-Dawely rats were implanted with telemetry probes and guide cannulae so that either muscimol or vehicle could be administered locally within the mPFC or dorsomedial hypothalamus (DMH). The heart rate and blood pressure of rats was continuously recorded as either muscimol or vehicle was administered centrally and rats were either exposed to restraint stress or left alone in their home cages. After the stress challenge, or equivalent period, rats that had received intra-mPFC injections were processed for immunohistochemical detection of Fos throughout the neuraxis. Bilateral microinjection of muscimol into the mPFC had no effect upon either baseline cardiovascular parameters or restraint stress-induced tachycardia or pressor responses whereas, in the DMH, pretreatment with muscimol attenuated the cardiovascular stress response. Analysis of Fos expression throughout the CNS of nonstressed rats showed no effect of muscimol injections into the mPFC on baseline expression in the nuclei examined. In contrast, rats that had received muscimol injections into their mPFC and were subsequently restrained exhibited an increase in the number of Fos-positive cells in the DMH, medial amygdala, and medial nucleus tractus solitarius as compared to vehicle-injected rats that experienced restraint stress. These results indicate that, during acute psychological stress, the mPFC does not modulate the cardiovascular system in rats but does inhibit specific subcortical nuclei to exert control over aspects of an integrated response to a stressor.
机译：本研究旨在确定内侧前额叶皮层（mPFC）（前缘和下缘区域）是否与应激反应的整合有关。将Sprague-Dawely大鼠植入遥测探针和引导插管，以便可以在mPFC或下丘脑下丘脑（DMH）内局部施用麝香酚或媒介物。连续记录大鼠的心率和血压，方法是集中施用麝香酚或媒介物，大鼠处于束缚压力下或独自呆在自己的笼子里。在应激挑战或相当时期后，对接受过mPFC内注射的大鼠进行处理，以在整个神经轴上对Fos进行免疫组织化学检测。在mPFC中双侧注射麝香酚对基线心血管参数或抑制应激诱导的心动过速或升压反应均无影响，而在DMH中，麝香酚预处理可减轻心血管应激反应。对整个非应激大鼠中枢神经系统Fos表达的分析表明，向mPFC注射麝香酚对所检查细胞核的基线表达没有影响。相比之下，与接受约束应激的媒介物注射的大鼠相比，接受了mPFC麝香酚注射并随后被抑制的大鼠的DMH，杏仁核和中间核孤立道中的Fos阳性细胞数量增加了。 。这些结果表明，在急性心理压力下，mPFC不会调节大鼠的心血管系统，但会抑制特定的皮层下核，从而控制对应激源的综合反应。

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