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首页> 外文期刊>The European Journal of Neuroscience >Rearrangement of the retino-collicular projection after partial optic nerve crush in the adult rat.
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Rearrangement of the retino-collicular projection after partial optic nerve crush in the adult rat.

机译：成年大鼠部分视神经被压迫后视网膜-视网膜投影的重排。

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摘要

The establishment of retino-collicular topography is a well-investigated model of axon pathfinding and it was believed that this topography is irreversibly fixed throughout life. We now report that, after partial crush of the adult rat optic nerve, the anterograde transport of intravitreally-injected tracers via axons of surviving retinal ganglion cells (RGC) in all retinal quadrants is confined to the rostro-medial part of the superior colliculus (SC). This indicates that the retino-collicular topography is rearranged after partial crush of the adult rat optic nerve. The reorganization starts in the injured optic nerve where surviving axonal fibres are demyelinized and bundled in the periphery of the optic nerve distal to the crush site. This is followed by a displacement of surviving axons to the medial part of the optic tract (OT) within 2 weeks. The infiltration of macrophages with the subsequent production of tumour necrosis factor-alpha at the lesion site is a prerequisite for the altered retino-collicular projection as blockade of tumour necrosis factor-alpha signalling with the neutralizing antibody Infliximab abolishes reorganization in the SC and lateralization of RGC axons in the optic nerve and OT. This suggests that optic nerve inflammation is necessary for a progressive bundling of surviving RGC axons, probably via clearance of cellular debris which, in turn, may lead to a redistribution of RGC axons to the medial OT and rostro-medial SC.
机译：视网膜-胶状体地形的建立是对轴突寻路的充分研究的模型，并且据信这种地形在整个生命中都是不可逆地固定的。我们现在报告，在部分挤压成年大鼠视神经后，通过所有视网膜象限中存活的视网膜神经节细胞（RGC）轴突的玻璃体注射示踪剂的顺行运输被限制在上丘的上睑内侧部分（ SC）。这表明成年大鼠视神经部分受压后，视网膜-胶状体地形会重新排列。重组从受伤的视神经开始，在那里存活的轴突纤维被脱髓鞘，并被束缚在挤压部位远端的视神经周围。接下来是在2周内将存活的轴突转移到视线（OT）的内侧部分。巨噬细胞浸润并在病变部位产生肿瘤坏死因子-α是改变视网膜-胶体投射的先决条件，因为用中和抗体英夫利昔单抗阻断肿瘤坏死因子-α信号传导可消除SC的重组和侧链化RGC轴突位于视神经和OT中。这表明视神经炎症对于生存的RGC轴突的渐进性捆绑是必要的，可能是通过清除细胞碎片，继而可能导致RGC轴突重新分布到内侧OT和rostro-内侧SC。

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