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首页> 外文期刊>The European Journal of Neuroscience >Direct visual and circadian pathways target neuroendocrine cells in primates.
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Direct visual and circadian pathways target neuroendocrine cells in primates.

机译：直接的视觉和昼夜节律途径靶向灵长类中的神经内分泌细胞。

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摘要

Abstract The effect of light on neuroendocrine functions is thought to be mediated through retinal inputs to the circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN). The present studies were conducted to provide experimental evidence for this signaling modality in non-human primates. In the St. Kitts vervet monkey, anterograde tracing of SCN efferents revealed a monosynaptic pathway between the circadian clock and hypothalamic neurons producing luteinizing hormone-releasing hormone (LHRH). Using a variety of tracing techniques, direct retinal input was found to be abundant in the SCN and in other hypothalamic sites. Strikingly, in hypothalamic areas other than the SCN, primary visual afferents established direct contacts with neuroendocrine cells including those producing LHRH and dopamine, neurons that are the hypothalamic regulators of pituitary gonadotrops and prolactin. Thus, our data reveal for the first time in primates that light stimuli can reach the hypothalamo-pituitary-gonadal axis, directly providing a pathway independent of but parallel to that of the circadian clock for the photic modulation of hormone release.
机译：摘要认为光对神经内分泌功能的影响是通过视网膜向昼夜节律起搏器下丘脑视交叉上核（SCN）的输入介导的。进行本研究以为非人灵长类动物中这种信号传导方式提供实验证据。在圣基茨黑猩猩猴子中，SCN传出的顺行性示踪显示昼夜节律与下丘脑神经元之间产生了促黄体生成激素释放激素（LHRH）的单突触途径。使用各种跟踪技术，发现直接视网膜输入在SCN和其他下丘脑部位很丰富。令人惊讶的是，在除SCN以外的下丘脑区域，初级视觉传入者与神经内分泌细胞建立了直接接触，包括产生LHRH和多巴胺的神经内分泌细胞，这些神经元是垂体促性腺激素和催乳激素的下丘脑调节剂。因此，我们的数据首次在灵长类动物中揭示了光刺激可以到达下丘脑-垂体-性腺轴，直接提供了与光生理调节激素释放的昼夜节律时钟独立但平行的途径。

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