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首页> 外文期刊>The European Journal of Neuroscience >Ultrastructural organization of medial prefrontal inputs to the rhinal cortices.
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Ultrastructural organization of medial prefrontal inputs to the rhinal cortices.

机译：鼻前皮质内侧前额叶输入的超微结构。

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Accumulating evidence suggests that the medial prefrontal cortex (mPFC) plays a critical role in the formation, retrieval and long-term storage of hippocampal-dependent memories. Consistent with this, there are direct hippocampal projections to the mPFC. Moreover, the mPFC sends robust projections to the perirhinal and entorhinal cortices, two interconnected cortical fields that funnel information into and out of the hippocampus. However, the significance of the latter projection remains unclear because no data are available regarding the rhinal targets of mPFC axons. This question was examined in the present study using a combination of anterograde tracing with Phaseolus vulgaris leucoagglutinin and pre-embedding gamma-aminobutyric acid (GABA) immunocytochemistry in guinea pigs. Following Phaseolus vulgaris leucoagglutinin injections in the mPFC, anterogradely labeled axons were seen in the perirhinal (mainly superficial layers) and lateral entorhinal (mainly deep layers) cortices. In the electron microscope, the synaptic articulation of anterogradely labeled mPFC axon terminals with perirhinal and entorhinal neurons was found to be nearly identical. In these two rhinal fields, mPFC axon terminals only formed asymmetric synapses, typically with GABA-immunonegative spines ( approximately 70%) but occasionally with dendritic profiles ( approximately 30%), half of which were GABA immunopositive. In the light of earlier observations, these findings indicate that mPFC inputs exert mainly excitatory effects in the rhinal cortices, prevalently on principal neurons. Thus, these results suggest that the mPFC may affect hippocampal-dependent memories by enhancing impulse traffic into and out of the hippocampus at the level of the rhinal cortices.
机译：越来越多的证据表明，内侧前额叶皮层（mPFC）在海马依赖性记忆的形成，恢复和长期储存中起着关键作用。与此相一致，海马投影直接指向mPFC。此外，mPFC将强健的投影发送到周围和皮质的皮质，这是两个相互关联的皮质区域，可将信息集中到海马中或从海马中漏出。但是，后一种预测的意义尚不清楚，因为没有有关mPFC轴突的鼻靶的数据。在本研究中，使用顺行追踪与菜豆白细胞凝集素和预先包埋的豚鼠γ-氨基丁酸（GABA）免疫细胞化学相结合，对这个问题进行了研究。在mPFC中注射菜豆的白细胞凝集素后，在周围的皮质（主要是浅层）和外侧的内嗅（主要是深层）皮质中看到了顺行标记的轴突。在电子显微镜下，发现顺行标记的mPFC轴突末端与周围神经和内嗅神经元的突触关节几乎相同。在这两个隆鼻场中，mPFC轴突末端仅形成不对称突触，通常具有GABA免疫棘突（约70％），但偶尔具有树突状分布（约30％），其中一半是GABA免疫阳性。根据早期的观察，这些发现表明mPFC输入主要在主要皮质神经元上对鼻皮质产生兴奋性作用。因此，这些结果表明，mPFC可能通过增强在鼻皮质水平上进出海马的冲动交通来影响海马依赖性记忆。

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