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首页> 外文期刊>The European Journal of Neuroscience >Neuromodulatory effects of gonadotropin-releasing hormone on retinotectal synaptic transmission in the optic tectum of rainbow trout.
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Neuromodulatory effects of gonadotropin-releasing hormone on retinotectal synaptic transmission in the optic tectum of rainbow trout.

机译：促性腺激素释放激素对虹鳟视神经上皮视网膜突触传递的神经调节作用。

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摘要

Gonadotropin-releasing hormone (GnRH) is a hypophysiotropic decapeptide that stimulates the release of gonadotropins from the pituitary. In addition, there are extra-hypothalamic GnRH neurons that project to all regions of the brain and whose function remains unknown. Here, we investigated the effects of GnRH on retinotectal synaptic transmission, the synapses of which are formed between retinal fibers and tectal periventricular neurons that express GnRH receptor mRNA. We used rainbow trout as our study model. The excitatory postsynaptic currents (EPSCs), which were evoked by electrical stimulation of the retinal fibers and recorded in periventricular neurons, were suppressed by antagonists of ionotropic glutamate receptors. EPSCs were increased by application of each of two types of GnRH (GnRH2 and GnRH3) in the trout tectum. Such facilitation lasted for at least 10 min after application of the GnRH. To our knowledge, this is the first report of GnRH modulating conventional synaptic transmission in the brain, suggesting that tectal GnRH enhances tectal sensitivity for retinal inputs. Furthermore, such long-lasting facilitation might occur across all the brain regions innervated by GnRH neurons, and GnRH might simultaneously switch neuronal activities in the brain regions relevant to reproductive behaviors.
机译：促性腺激素释放激素（GnRH）是促体垂力的十肽，它刺激垂体释放促性腺激素。此外，还有下丘脑GnRH神经元投射到大脑的所有区域，其功能仍然未知。在这里，我们研究了GnRH对视网膜-皮层突触传递的影响，其突触是在视网膜纤维和表达GnRH受体mRNA的顶盖脑室周围神经元之间形成的。我们以虹鳟鱼为研究模型。电离性谷氨酸受体拮抗剂可抑制由视网膜纤维的电刺激引起的兴奋性突触后电流（EPSC），并记录在脑室周围神经元中。通过在鳟鱼的顶盖中施用两种类型的GnRH（GnRH2和GnRH3）来增加EPSC。施用GnRH后，这种促进作用至少持续了10分钟。据我们所知，这是GnRH调节大脑中常规突触传递的第一份报道，提示tecntal GnRH增强了视网膜对视网膜的敏感性。此外，这种持久的促进作用可能发生在受GnRH神经元支配的所有大脑区域，而GnRH可能同时切换与生殖行为有关的大脑区域的神经元活动。

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