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首页> 外文期刊>The European Journal of Neuroscience >Individual neurons in the caudal fastigial oculomotor region convey information on both macro- and microsaccades
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Individual neurons in the caudal fastigial oculomotor region convey information on both macro- and microsaccades

机译：尾部小脑动眼神经区域的单个神经元传递有关大扫视和微扫视的信息

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Recent studies have suggested that microsaccades, the small amplitude saccades made during fixation, are precisely controlled. Two lines of evidence suggest that the cerebellum plays a key role not only in improving the accuracy of macrosaccades but also of microsaccades. First, lesions of the fastigial oculomotor regions (FOR) cause horizontal dysmetria of both micro-and macrosaccades. Secondly, our previous work on Purkinje cell simple spikes in the oculomotor vermis (OV) has established qualitatively similar response preferences for these two groups of saccades. In this work, we investigated the control signals for micro- and macrosaccades in the FOR, the target of OV Purkinje cell axons. We found that the same FOR neurons discharged for micro-and macrosaccades. For both groups of saccades, FOR neurons exhibited very similar dependencies of their discharge strength on direction and amplitude and very similar burst onset time differences for ipsi-and contraversive saccades and, in both, response duration reflected saccade duration, at least at the population level. An intriguing characteristic of microsaccade-related responses is that immediate pre-saccadic firing rates decreased with distance to the target center, a pattern that strikingly parallels the eye position dependency of both microsaccade metrics and frequency, which may suggest a potential neural mechanism underlying the role of FOR in fixation. Irrespective of this specific consideration, our study supports the view that microsaccades and macrosaccades share the same cerebellar circuitry and, in general, further strengthens the notion of a microsaccade-macrosaccade continuum.
机译：最近的研究表明，微扫视是固定过程中产生的小振幅扫视，可以精确控制。有两点证据表明，小脑不仅在改善大扫视的准确性方面而且在微扫视的准确性方面都起着关键作用。首先，小脑顶眼动眼区域（FOR）的病变会引起微扫视和大扫视的水平不对称。其次，我们先前对动眼ver（OV）中的Purkinje细胞简单尖峰的研究已经为这两组扫视建立了定性相似的响应偏好。在这项工作中，我们调查了OV Purkinje细胞轴突的目标FOR中的微扫视和大扫视的控制信号。我们发现，相同的FOR神经元释放出微扫视和大扫视。对于两组扫视，FOR神经元的放电强度对方向和振幅的依赖性非常相似，并且对于ipsi和对立扫视均表现出非常相似的爆发开始时间差异，并且在这两者中，响应持续时间至少在总体水平上反映了扫视持续时间。 。微扫视相关反应的一个引人入胜的特征是，眼跳前的即时射击率会随着距目标中心距离的增加而降低，该模式与微扫视指标和频率对眼睛位置的依赖性显着平行，这可能暗示了潜在的神经机制固定的FOR。不管这种具体考虑如何，我们的研究都支持微扫视和大扫视共享相同的小脑回路的观点，并且总体上进一步增强了微扫视-大扫视连续体的概念。

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