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首页> 外文期刊>The European physical journal, D. Atomic, molecular, and optical physics >Specific cationic emission of cisplatin following ionization by swift protons
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Specific cationic emission of cisplatin following ionization by swift protons

机译：快速质子电离后顺铂的特定阳离子发射

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We have investigated collision-induced ionization and fragmentation by 100 keV protons of the radio sensitizing molecule cisplatin, which is used in cancer treatments. A large emission of HCl+ and NH2+ is observed, but surprisingly, no cationic fragments containing platinum are detected, in contrast to ionization-dissociation induced by electronic collision. Theoretical investigations show that the ionization processes take place on platinum and on chlorine atoms. We propose new ionization potentials for cisplatin. Dissociation limits corresponding to the measured fragmentation mass spectrum have been evaluated and the theoretical results show that the non-observed cationic fragments containing platinum are mostly associated with low dissociation energies. We have also investigated the reaction path for the hydrogen transfer from the NH3 group to the Cl atom, as well as the corresponding dissociation limits from this tautomeric form. Here again the cations containing platinum correspond to lower dissociation limits. Thus, the experimental results suggest that excited states, probably formed via inner-shell ionization of the platinum atom of the molecule, correlated to higher dissociation limits are favored.
机译：我们已经研究了放射致敏分子顺铂的100 keV质子碰撞诱导的电离和碎片化，这是用于癌症治疗的。观察到大量的HCl +和NH2 +排放，但是令人惊讶的是，与电子碰撞引起的电离解离相反，没有检测到含铂的阳离子片段。理论研究表明，电离过程发生在铂和氯原子上。我们提出了顺铂的新电离势。已经评估了与测得的碎片质谱对应的解离极限，并且理论结果表明，未观察到的含铂阳离子片段主要与低解离能有关。我们还研究了氢从NH3基团转移到Cl原子的反应路径，以及从该互变异构体形式的解离极限。在此，含铂的阳离子再次对应于较低的解离极限。因此，实验结果表明，可能是通过分子中铂原子的内壳电离形成的激发态，与更高的解离限相关。

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