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首页> 外文期刊>The British Journal of Nutrition >The gut microbiome of kittens is affected by dietary protein:carbohydrate ratio and associated with blood metabolite and hormone concentrations.
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The gut microbiome of kittens is affected by dietary protein:carbohydrate ratio and associated with blood metabolite and hormone concentrations.

机译：小猫的肠道微生物组受饮食蛋白质：碳水化合物比例的影响，并与血液代谢产物和激素浓度有关。

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High-protein, low-carbohydrate (HPLC) diets are common in cats, but their effect on the gut microbiome has been ignored. The present study was conducted to test the effects of dietary protein:carbohydrate ratio on the gut microbiota of growing kittens. Male domestic shorthair kittens were raised by mothers fed moderate-protein, moderate-carbohydrate (MPMC; n 7) or HPLC (n 7) diets, and then weaned at 8 weeks onto the same diet. Fresh faeces were collected at 8, 12 and 16 weeks; DNA was extracted, followed by amplification of the V4-V6 region of the 16S rRNA gene using 454 pyrosequencing. A total of 384 588 sequences (average of 9374 per sample) were generated. Dual hierarchical clustering indicated distinct clustering based on the protein:carbohydrate ratio regardless of age. The protein:carbohydrate ratio affected faecal bacteria. Faecal Actinobacteria were greater (P< 0.05) and Fusobacteria were lower (P< 0.05) in MPMC-fed kittens. Faecal Clostridium, Faecalibacterium, Ruminococcus, Blautia and Eubacterium were greater (P< 0.05) in HPLC-fed kittens, while Dialister, Acidaminococcus, Bifidobacterium, Megasphaera and Mitsuokella were greater (P< 0.05) in MPMC-fed kittens. Principal component analysis of faecal bacteria and blood metabolites and hormones resulted in distinct clusters. Of particular interest was the clustering of blood TAG with faecal Clostridiaceae, Eubacteriaceae, Ruminococcaceae, Fusobacteriaceae and Lachnospiraceae; blood ghrelin with faecal Coriobacteriaceae, Bifidobacteriaceae and Veillonellaceae; and blood glucose, cholesterol and leptin with faecal Lactobacillaceae. The present results demonstrate that the protein:carbohydrate ratio affects the faecal microbiome, and highlight the associations between faecal microbes and circulating hormones and metabolites that may be important in terms of satiety and host metabolism
机译：高蛋白，低碳水化合物（HPLC）的饮食在猫中很常见，但是它们对肠道微生物组的影响却被忽略了。进行本研究以测试日粮蛋白质：碳水化合物比例对正在生长的小猫的肠道菌群的影响。饲喂中等蛋白，中等碳水化合物（MPMC; n 7）或HPLC（n 7）饮食的母亲抚养雄性短毛猫小猫，然后在第8周断奶至相同饮食。在第8、12和16周时收集新鲜的粪便。提取DNA，然后使用454焦磷酸测序法扩增16S rRNA基因的V4-V6区。总共产生了384 588个序列（每个样品平均9374个序列）。双重分层聚类表明基于蛋白质：碳水化合物比例的不同聚类，与年龄无关。蛋白质：碳水化合物比影响粪便细菌。用MPMC喂养的小猫的粪便放线杆菌较高（P <0.05），而梭菌属较低（P <0.05）。饲喂HPLC的小猫的粪便梭菌，费氏杆菌，鲁米诺球菌，Blautia和真细菌更大（P <0.05），而MPMC饲喂的猫中Dialial，酸氨基球菌，双歧杆菌，巨球藻和Mitsuokella更大（P <0.05）。粪便细菌，血液代谢产物和激素的主成分分析导致了不同的簇。特别令人感兴趣的是血液TAG与粪便梭菌科，真细菌科，Ruminococcaceae，Fusobacteriaceae和Lachnospiraceae的聚集。血液生长素释放肽与粪便肠杆菌科细菌，双歧杆菌科细菌和Veillonellaceae;以及粪乳杆菌科的血糖，胆固醇和瘦素。目前的结果表明蛋白质：碳水化合物的比率影响粪便微生物组，并强调了粪便微生物与循环激素和代谢产物之间的关联，这对饱腹感和宿主代谢可能很重要

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