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首页> 外文期刊>The British Journal of Nutrition >Role of neonatal hyperleptinaemia on serum adiponectin and suppressor of cytokine signalling-3 expression in young rats
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Role of neonatal hyperleptinaemia on serum adiponectin and suppressor of cytokine signalling-3 expression in young rats

机译：新生高轻血症对幼年大鼠血清脂联素和细胞因子信号传导3表达的抑制作用

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摘要

Previously we had shown that neonatal leptin treatment programmes for both hyperleptinaemia and hyperinsulinaemia, which lead to leptin resistance and low expression of the hypothalamic leptin receptor (OB-Rb) of rats aged 150 d. Here we investigated in young post-weaned rats (age 30 d) if leptin treatment during lactation induces leptin and insulin resistance and if those changes are accompanied by changes in the suppressor of cytokine signalling-3 (SOCS-3) expression and serum adiponectin concentration. After delivery, the pups were divided into two groups: (1) a leptin group (Lep) that were injected with leptin daily (8 mug/100 g body weight subcutaneously) for the first 10 d of lactation; (2) a control (C) group, receiving saline. After weaning (day 21), body weight was monitored until the animals were age 30 d. They were tested for food intake in response to either leptin (0.5 mg/kg body weight intraperitoneally) (CL, LepL) or saline (CSal, LepSal) when they were aged 30 d. The CL group showed lower food intake, but no response was observed in the LepL group, suggesting leptin resistance. The Lep group had hyperleptinaemia (five-fold), hyperinsulinaemia (+42.5 %) and lower levels of serum adiponectin ( - 43.2 %). The hypothalamic expression of OB-Rb was lower ( - 22 %) and SOCS-3 was higher (+52.8 %) in the Lep group. We conclude that neonatal leptin treatment programmes for leptin resistance as soon as 30 d and suggests that SOCS-3 appears to be of particular importance in this event. In the Lep group, the lower serum adiponectin levels were accompanied by higher serum insulin, indicating a probable insulin resistance.
机译：以前，我们已经证明了针对高脂血症和高胰岛素血症的新生儿瘦素治疗方案，可导致150 d大鼠的瘦素抵抗和下丘脑瘦素受体（OB-Rb）的低表达。在这里，我们研究了年轻的断奶大鼠（30天龄）是否在泌乳期间进行瘦素治疗诱导了瘦素和胰岛素抵抗，以及这些变化是否伴随着细胞因子信号传导抑制因子3（SOCS-3）表达和血清脂联素浓度的变化。 。分娩后，将幼崽分为两组：（1）瘦素组（Lep），在哺乳的前10天每天注射瘦素（皮下注射8马克杯/ 100 g体重）; （2）对照组（C），接受生理盐水。断奶后（第21天），监测体重，直到动物30天。当他们在30 d时对瘦素（腹膜内0.5毫克/千克体重）（CL，LepL）或生理盐水（CSal，LepSal）做出反应，测试他们的食物摄入。 CL组食物摄入量较低，但LepL组未观察到反应，表明瘦素抵抗。 Lep组的高脂蛋白血症（五倍），高胰岛素血症（+ 42.5％）和较低的血清脂联素水平（-43.2％）。在Lep组中，OB-Rb的下丘脑表达较低（-22％），SOCS-3较高（+ 52.8％）。我们得出的结论是，针对瘦素抵抗力的新生儿瘦素治疗方案最早可在30天后完成，并表明SOCS-3在这一事件中显得尤为重要。在Lep组中，较低的血清脂联素水平伴随较高的血清胰岛素水平，表明可能存在胰岛素抵抗。

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