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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Serum Antioxidant Levels Associated with Subcortical Ischemic Vascular Disease
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Serum Antioxidant Levels Associated with Subcortical Ischemic Vascular Disease

机译：皮层下缺血性血管疾病相关的血清抗氧化水平

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Objective: We aimed to examine changes in serum bilirubin and uric acid (UA) levels in subcortical ischemic vascular disease (SIVD). In addition, we investigated if altered serum bilirubin and UA levels correlate with the subtypes of SIVD as well as the severity of leukoaraiosis (LA). Methods: This cross-sectional study included 1098 consecutive patients with slight symptoms, such as dizziness, vertigo etc. According to magnetic resonance imaging (MRI) appearances, they were divided into either SIVD group or controls (CN), and the SIVD group was further grouped in lacunar infarction (LI) and LA subtypes, as well as different grades. Serum bilirubin and UA levels were determined by the vanadate oxidase method and enzymatic method respectively, after at least an eight hour overnight fasting, in all subjects. Results: The bilirubin level was obviously lower while the UA level was significantly higher in the SIVD group when compared with the controls. Moreover, the LA subgroup presented more significant changes in bilirubin and UA when compared to the LI subgroup in both males and females. The correlation was positive between the UA levels and the LA severity (r=0.134,p=0.006). Multivariate regression analysis revealed that the odds ratio (95% CI) for SIVD in the lowest tertile of total bilirubin (Tbil<9.58 mu mol/L) and highest tertile of UA (UA>339 mu mol/L) were 2.702(1.936-3.770) and 2.135(1.521-2.996) respectively after adjusting for confounding variables. Conclusion: Serum bilirubin levels were lower, whereas UA levels were higher in SIVD patients when compared with controls in both males and females, especially in LA patients. Moreover, serum UA levels positively correlated to LA severity.
机译：目的：我们旨在检查皮下缺血性血管病（SIVD）的血清胆红素和尿酸（UA）水平的变化。此外，我们调查了血清胆红素和UA水平的改变是否与SIVD的亚型以及白细胞软化症（LA）的严重程度相关。方法：该横断面研究包括1098例连续出现轻微症状（如头晕，眩晕等）的患者。根据磁共振成像（MRI）的表现，将其分为SIVD组或对照组（CN），SIVD组为进一步分为腔隙性梗塞（LI）和LA亚型，以及不同等级。在所有受试者中，禁食至少八小时后，分别通过钒酸盐氧化酶法和酶法测定血清胆红素和UA水平。结果：与对照组相比，SIVD组的胆红素水平明显降低，而UA水平则明显升高。此外，与男性和女性的LI亚组相比，LA亚组在胆红素和UA方面表现出更显着的变化。 UA水平和LA严重程度之间呈正相关（r = 0.134，p = 0.006）。多元回归分析显示，在总胆红素最低的三分位数（Tbil <9.58μmol/ L）和UA最高的三分位数（UA> 339μmol/ L）中，SIVD的优势比（95％CI）为2.702（1.936-调整混杂变量后分别为3.770）和2.135（1.521-2.996）。结论：与对照组相比，SIVD患者的血清胆红素水平较低，而UA水平则较高，尤其是在LA患者中。此外，血清UA水平与LA的严重程度呈正相关。

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