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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry.
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Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry.

机译：海洋链霉菌具有很高的抗疟疾活性的抗癌和抗菌三恶花胶及其绝对立体化学。

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摘要

The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those of known derivatives. The absolute configuration of the trioxacarcins is deduced from the X-ray analysis of gutingimycin (2g) and from the known stereochemistry of the L-trioxacarcinoses A and B.
机译：链霉菌种的乙酸乙酯提取物。分离物B8652将三氧沙金星菌素A递送至约C（2a至约2c），另外将三个新的称为三氧金刚菌素D的衍生物递送至约F（2d至约2f）。所有的三氧杂rc呤都显示出很高的抗菌作用，其中一些具有很高的抗肿瘤和抗疟疾活性。新的抗生素的结构源自质谱，1D和2D NMR光谱，并通过NMR数据与已知衍生物的比较得到了证实。三氟沙汀的绝对构型是从古丁霉素（2g）的X射线分析以及L-三氧嘧啶A和B的已知立体化学中得出的。

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