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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Induced sclerotium formation exposes new bioactive metabolites from Aspergillus sclerotiicarbonarius.
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Induced sclerotium formation exposes new bioactive metabolites from Aspergillus sclerotiicarbonarius.

机译：诱导的菌核形成暴露了来自碳核菌的新的生物活性代谢产物。

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摘要

Sclerotia are known to be fungal survival structures, and induction of sclerotia may prompt production of otherwise undiscovered metabolites. Aspergillus sclerotiicarbonarius (IBT 28362) was investigated under sclerotium producing conditions, which revealed a highly altered metabolic profile. Four new compounds were isolated from cultivation under sclerotium formation conditions and their structures elucidated using different analytical techniques (HRMS, UV, 1D and 2D NMR). This included sclerolizine, an alkylated and oxidized pyrrolizine, the new emindole analog emindole SC and two new carbonarins; carbonarins I and J. We have identified the three latter as true sclerotial metabolites. All metabolites were tested for antifungal and antiinsectan activity, and sclerolizine and carbonarin I displayed antifungal activity against Candida albicans, while all four showed antiinsectan activity. These results demonstrate induction of sclerotia as an alternative way of triggering otherwise silent biosynthetic pathways in filamentous fungi for the discovery of novel bioactive secondary metabolites.
机译：已知核盘菌是真菌存活结构，并且核盘菌的诱导可能促使产生未发现的代谢产物。在菌核产生条件下研究了菌核糖曲霉（IBT 28362）。在菌核形成条件下从培养物中分离出四种新化合物，并使用不同的分析技术（HRMS，UV，1D和2D NMR）阐明了它们的结构。其中包括巩膜哌嗪，烷基化和氧化的吡咯嗪，新的emindole类似物emindole SC和两个新的碳芳烃。 Carbonarins I和J。我们已将后者确定为真正的硬化代谢产物。测试了所有代谢物的抗真菌和抗昆虫活性，而巩膜碱和碳素I表现出对白色念珠菌的抗真菌活性，而所有四个都显示出抗昆虫活性。这些结果表明，菌核的诱导是触发丝状真菌中原本沉默的生物合成途径的另一种方法，用于发现新的具有生物活性的次生代谢产物。

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