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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Impairment of absorption of digoxin by acarbose.
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Impairment of absorption of digoxin by acarbose.

机译：阿卡波糖对地高辛吸收的损害。

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摘要

This study was conducted to determine the effect of acarbose on serum concentrations of digoxin in healthy male volunteers. A randomized crossover design with three phases was used. In phase 1 participants received 0.5 mg of digoxin alone. In phase 2 they received 0.5 mg of digoxin 0.5 hours after a 200-mg dose of acarbose. In phase 3 they received 100 mg of acarbose 0.5 hours before each meal three times daily for 3 days. On the fourth day, they received 0.5 mg of digoxin 0.5 hours after a 100-mg dose of acarbose. Area under the concentration-time curve (AUC0-48) and mean maximum concentration (Cmax) were significantly lower and tmax significantly increased in phases 2 and 3 compared with phase 1. These results indicate that the absorption of digoxin is reduced by administration of acarbose, and that one of the major mechanisms of this interaction may be due to the pharmacodynamics of acarbose.
机译：进行这项研究以确定阿卡波糖对健康男性志愿者血清中地高辛浓度的影响。使用具有三个阶段的随机交叉设计。在第1阶段，参与者仅接受0.5 mg的地高辛。在阶段2中，他们在200毫克阿卡波糖剂量0.5小时后接受了0.5毫克地高辛。在第3阶段，他们在每餐前0.5小时接受3天的每日一次三小时的100毫克阿卡波糖。在第四天，他们在100毫克阿卡波糖剂量0.5小时后接受了0.5毫克地高辛。与阶段1相比，阶段2和3中浓度-时间曲线下的面积（AUC0-48）和平均最大浓度（Cmax）显着降低，tmax显着增加。这些结果表明，施用阿卡波糖可降低地高辛的吸收，并且这种相互作用的主要机制之一可能是由于阿卡波糖的药效学。

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