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首页> 外文期刊>The journal of clinical psychiatry >A 1-year follow-up study of behavioral and psychological symptoms in dementia among people in care environments.
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A 1-year follow-up study of behavioral and psychological symptoms in dementia among people in care environments.

机译：为期一年的随访研究，研究了护理环境中痴呆症患者的行为和心理症状。

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BACKGROUND: Behavioral and psychological symptoms in dementia (BPSD) are common and distressing for patients and caregivers, but little is known about the natural history of these symptoms, particularly among patients in care facilities. This information is essential for informed clinical management. We report a 1-year follow-up study of the prevalence, incidence, and outcome of the 3 main BPSD (agitation, depression, and psychosis) in care facilities. METHOD: 136 elderly residents with dementia (29% living in social care facilities and 71% in nursing home care) were assessed longitudinally on 2 occasions a year apart using a range of standardized psychiatric schedules, including the Neuropsychiatric Inventory. RESULTS: The overall prevalence of BPSD was stable over the year (76% at baseline and 82% at follow-up). Subjects with subclinical symptoms at baseline were more likely to develop clinically significant BPSD during follow-up than those who were symptom free (83% vs. 52%; Mann-Whitney U test, z = 2.36, p = .01). Agitation was the most common individual syndrome (55%). Although overall BPSD were persistent, > or = 45% of dementia patients with any of the major syndromes experienced resolution, indicating the development of different BPSD in many residents. There was no evidence that residents taking neuroleptics were more likely to experience resolution of BPSD than neuroleptic-free residents. CONCLUSION: BPSD are highly frequent and persistent among residents of care facilities with dementia. This emphasizes the need for ongoing treatment trials. The pattern of resolution with the development of new symptoms indicates that short focused periods of treatment may be a more effective management approach. In addition, the potential value in treating patients with subclinical BPSD to prevent the development of full-blown syndromes needs to be investigated.
机译：背景：痴呆症（BPSD）的行为和心理症状对于患者和护理人员来说是常见且令人不安的，但对这些症状的自然病程知之甚少，尤其是在护理机构的患者中。此信息对于明智的临床管理至关重要。我们报告了对护理机构中3种主要BPSD（躁动，抑郁和精神病）的患病率，发生率和结局的1年随访研究。方法：采用包括神经精神病学调查表在内的一系列标准化精神病学时间表，每年两次分别对136名老年痴呆症患者（29％的人住在社会护理机构和71％的养老院）进行纵向评估。结果：BPSD的总体患病率一年内保持稳定（基线时为76％，随访时为82％）。与无症状的受试者相比，基线时具有亚临床症状的受试者更有可能在临床上发展出具有临床意义的BPSD（83％比52％; Mann-Whitney U检验，z = 2.36，p = 0.01）。躁动是最常见的个体综合症（55％）。尽管总体BPSD持续存在，但≥45％的患有任何主要综合征的痴呆患者经历了消退，这表明许多居民中出现了不同的BPSD。没有证据表明服用抗精神病药的居民比没有抗精神病药的居民更有可能经历BPSD的缓解。结论：在患有痴呆症的医疗机构中，BPSD的发生频率很高且持续存在。这强调了正在进行的治疗试验的必要性。随着新症状的发展而解决的模式表明，短期集中治疗可能是一种更有效的治疗方法。此外，还需要研究在亚临床BPSD治疗中预防成熟综合征发展的潜在价值。

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