Case of paraneoplastic pemphigus with immunoglobulin (Ig)G and IgA antibodies to various antigens

Otsuka Yohei; Ueno Takashi; Yamase Aya; Ito Michiko; Osada Shinichi; Kawana Seiji; Funasaka Yoko; Teye Kwesi; Ishii Norito; Hashimoto Takashi; Saeki Hidehisa

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Case of paraneoplastic pemphigus with immunoglobulin (Ig)G and IgA antibodies to various antigens

机译：伴有多种抗原的免疫球蛋白（Ig）G和IgA抗体的副肿瘤性天疱疮病例

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A 63-year-old Japanese man with non-Hodgkin B-cell lymphoma presented with erythematous skin lesions on his entire body, with oral, ocular and anal mucosal lesions. The patient was diagnosed with paraneoplastic pemphigus. Immunofluorescence showed both immunoglobulin (Ig)G and IgA antibodies to keratinocyte cell surfaces. Various immunoblot and enzyme-linked immunosorbent assays showed both IgG and IgA antibodies to various autoantigens, including desmogleins, desmocollins, envoplakin, periplakin and bullous pemphigoid antigens. This was a unique case with a very rare autoantibody profile in paraneoplastic pemphigus.

机译：一名63岁的日本男子患有非霍奇金B细胞淋巴瘤，其全身均出现红斑性皮肤病变，并出现口腔，眼部和肛门粘膜病变。该患者被诊断为副肿瘤性天疱疮。免疫荧光显示针对角质形成细胞表面的免疫球蛋白（Ig）G和IgA抗体。各种免疫印迹和酶联免疫吸附试验均显示针对各种自身抗原的IgG和IgA抗体，包括桥粒芯糖蛋白，桥粒胶体蛋白，envoplakin，periplakin和大疱性类天疱疮抗原。这是在副肿瘤性天疱疮中罕见的自身抗体谱的独特病例。

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来源
《The Journal of dermatology》 |2016年第8期|共3页
作者
Otsuka Yohei; Ueno Takashi; Yamase Aya; Ito Michiko; Osada Shinichi; Kawana Seiji; Funasaka Yoko; Teye Kwesi; Ishii Norito; Hashimoto Takashi; Saeki Hidehisa;
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正文语种 eng
中图分类皮肤病学与性病学;
关键词
autoantibody; desmocollin; enzyme-linked immunosorbent assay; immunoblot; paraneoplastic pemphigus;

机译：自身抗体;去粘胶蛋白;酶联免疫吸附法;免疫印迹;副肿瘤天疱疮;

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专利

1. Case of paraneoplastic pemphigus with immunoglobulin (Ig)G and IgA antibodies to various antigens [J] . Otsuka Yohei, Ueno Takashi, Yamase Aya, The Journal of dermatology . 2016,第8期

机译：伴有多种抗原的免疫球蛋白（Ig）G和IgA抗体的副肿瘤性天疱疮病例
2. Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus [J] . Adriana Maria Porro, Laura De Sena Nogueira Maehara, Livia De Vasconcelos Nasser Caetano, Anais Brasileiros de Dermatologia . 2014,第1期

机译：天疱疮的非经典形式：天疱疮天疱疮，IgA天疱疮，副肿瘤天疱疮和IgG / IgA天疱疮
3. A monoclonal antibody against the paraneoplastic pemphigus (PNP) antigen, envoplakin: cDNA sequences encoding the variable regions of heavy and light chains [J] . Ahn JH, Lee MG, Kim SC, Molecules and cells . 2004,第2期

机译：抗副肿瘤性天疱疮（PNP）抗原的单克隆抗体，envoplakin：编码重链和轻链可变区的cDNA序列
4. Clinical course prognosis for the autoimmune pemphigus by evaluation of the character of immunoglobulin fixing in sites of antigen targets localization [C] . Makhneva Natalia V., Davidenko Elena B., Beletskaya Ludmila V. World Asthma COPD Forum . 2011

机译：通过评价抗原靶向局部地区免疫球蛋白固定的抗免疫球蛋白特征的临床课程预后
5. The antibody response in haddock (Melanogrammus aeglefinus ): Partial characterization and comparison of the immunoglobulin structure and the Ig heavy variable genes. [D] . Bentley, Breagh Erin. 2003

机译：黑线鳕（Melanogrammus aeglefinus）中的抗体反应：免疫球蛋白结构和Ig重可变基因的部分表征和比较。
6. Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. [O] . M Amagai, T Nishikawa, H C Nousari, 1998

机译：患有副肿瘤性天疱疮的患者血清中存在抗桥粒芯蛋白3（寻常性天疱疮抗原）的抗体并在体内引起新生小鼠体内的棘皮松解症。
7. Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. [O] . Amagai, M, Nishikawa, T, Nousari, H C, 1998

机译：患有副肿瘤性天疱疮的患者的血清中存在抗桥粒芯蛋白3（寻常性天疱疮抗原）的抗体，并在体内引起新生小鼠体内的棘皮松解症。
8. B Cells from M167 Mu Kappa Transgenic Mice Fail to Proliferate after Stimulationwith Soluble Anti-Ig Antibodies. A Model for Antigen-Induced B Cell Anergy. (Reannouncement with New Availability Information) [R] . Sieckmann, D. G., Holmes, K., Hornbeck, P., 1994

机译：来自m167 mu Kappa转基因小鼠的B细胞在用可溶性抗Ig抗体刺激后不能增殖。抗原诱导B细胞无能的模型。（重新公布新的可用性信息）

Case of paraneoplastic pemphigus with immunoglobulin (Ig)G and IgA antibodies to various antigens

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