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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Prevalence of glucose-6-phosphate dehydrogenase deficiency in jaundiced Egyptian neonates
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Prevalence of glucose-6-phosphate dehydrogenase deficiency in jaundiced Egyptian neonates

机译：黄疸埃及新生儿中6-磷酸葡萄糖脱氢酶缺乏症的患病率

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Background: The enzyme, Glucose-6-phosphate dehydrogenase (G6PD), deficiency leads to impaired production of reduced glutathione and predisposes the red cells to be damaged by oxidative metabolites, causing hemolysis. Deficient neonates may manifest clinically as hyperbilirubinemia or even kernicterus.Objective: This study was carried out to detect erythrocyte G6PD deficiency in neonatal hyperbilirubinemia.Methods and design: To determine the frequency and effect of G6PD deficiency, this study was conducted on 202 neonates with indirect hyperbilirubinemia. All term and preterm babies up to 13day of age admitted with clinically evident jaundice were taken for the study. G6PD activity is measured by the UV-Kinetic Method using cellular enzyme determination reagents by spectrophotometry according to manufacturer's instructions.Results: A total of 202 babies were enrolled in this study. Male babies outnumbered the female (71.3% versus 28.7%). Mean age of the study newborns was 3.752.5 days. Eighteen neonates (8.9%) had G6PD deficiency, all are males. One case had combined G6PD deficiency and RH incompatibility. Mean serum total bilirubin was 17.2 +/- 4.4 in G6PD deficient cases. There was significant positive correlation between the time of appearance of jaundice in days and G6PD levels in G6PD deficient cases.Conclusion: Neonatal hyperbilirubinemia is associated with various clinical comorbidities. G6PD deficiency is found to one important cause of neonatal jaundice developing on day 2 onwards.
机译：背景：6-磷酸葡萄糖脱氢酶（G6PD）缺乏会导致还原型谷胱甘肽的产生受损，并使红细胞容易被氧化代谢产物破坏，导致溶血。缺乏的新生儿在临床上可能表现为高胆红素血症或什至是kernerterus。目的：本研究旨在检测新生儿高胆红素血症中红细胞G6PD缺乏症。方法和设计：为确定G6PD缺乏症的发生频率和影响，该研究针对202例间接性新生儿进行高胆红素血症。接受所有临床上明显黄疸的不超过13天的足月和早产婴儿进行研究。根据制造商的说明，使用细胞酶测定试剂通过分光光度法，通过UV动力学方法测量G6PD活性。结果：本研究共纳入202名婴儿。男性婴儿超过女性（71.3％比28.7％）。研究新生儿的平均年龄为3.752.5天。 18名新生儿（8.9％）患有G6PD缺乏症，均为男性。 1例合并G6PD缺乏和RH不相容。在G6PD缺陷病例中，平均血清总胆红素为17.2 +/- 4.4。结论：新生儿高胆红素血症与多种临床合并症相关，其中黄疸发生时间与G6PD缺乏症患者的G6PD水平呈显着正相关。发现G6PD缺乏是第二天开始发生新生儿黄疸的重要原因。

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