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Characterization of peak purity by fast multiscan circular dichroism detection

机译:通过快速多扫描圆二色谱检测峰纯度

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摘要

A method has been developed to detect inhomogeneity of apparently homogeneous peaks of very similar analytes, The method utilizes the rapid scan feature of state-of-the-art spectrometers/detectors that allow the recording of up to 30 spectra in a single chromatographic peak. Sensitivity and selectivity are enhanced by chiroptical/optical detection. Thus, identification of "front" and "rear" components of the peak can be carried out. The method is exemplified by mixtures of codeine, hydrocodone and oxycodone as analytes. [References: 13]
机译:已开发出一种方法来检测非常相似的分析物的表观均质峰的不均匀性。该方法利用了最新的光谱仪/检测器的快速扫描功能,可在单个色谱峰中记录多达30个光谱。整脊/光学检测提高了灵敏度和选择性。因此,可以进行峰的“前”和“后”成分的鉴定。该方法以可待因,氢可酮和羟考酮的混合物作为分析物的例子。 [参考:13]

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