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首页> 外文期刊>The Journal of pediatrics >Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy: a prospective, randomized study with a follow-up to the age of 2 years.
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Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy: a prospective, randomized study with a follow-up to the age of 2 years.

机译：对患有牛奶过敏的婴儿对大豆配方奶粉和广泛水解的乳清配方奶粉的过敏：一项前瞻性随机研究，随访至2岁。

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OBJECTIVES: We conducted a prospective, randomized study to evaluate the cumulative incidence of allergy or other adverse reactions to soy formula and to extensively hydrolyzed formula up to the age of 2 years in infants with confirmed cow's milk allergy. STUDY DESIGN: Infants (n = 170) with documented cow's milk allergy were randomly assigned to receive either a soy formula or an extensively hydrolyzed formula. If it was suspected that the formula caused symptoms, a double-blind, placebo-controlled challenge (DBPCFC) with the formula was performed. The children were followed to the age of 2 years, and soy-specific immunoglobulin E antibodies were measured at the time of diagnosis and at the ages of 1 and 2 years. RESULTS: An adverse reaction to the formula was confirmed by challenge in 8 patients (10%; 95% confidence interval, 4.4%-18.8%) randomly assigned to soy formula and in 2 patients (2.2%; 95% confidence interval, 0.3% to 7.8%) randomly assigned to extensively hydrolyzed formula. Adverse reactions to soy were similar in IgE-associated and non-IgE-associated cow's milk allergy (11% and 9%, respectively). IgE to soy was detected in only 2 infants with an adverse reaction to soy. Adverse reactions to soy formula were more common in younger (<6 months) than in older (6 to 12 months) infants (5 of 20 vs 3 of 60, respectively, P =.01). CONCLUSIONS: Soy formula was well tolerated by most infants with IgE-associated and non-IgE-associated cow's milk allergy. Development of IgE-associated allergy to soy was rare. Soy formula can be recommended as a first-choice alternative for infants >or=6 months of age with cow's milk allergy.
机译：目的：我们进行了一项前瞻性随机研究，以评估对已确认对牛奶过敏的婴儿对大豆配方食品和广泛水解配方食品的过敏或其他不良反应的累积发生率，直至2岁。研究设计：随机记录有牛奶过敏记录的婴儿（n = 170）接受大豆配方食品或广泛水解的配方食品。如果怀疑该配方引起症状，则对该配方进行双盲，安慰剂对照攻击（DBPCFC）。对儿童进行跟踪，直至2岁，并在诊断时以及1岁和2岁时测量了大豆特异性免疫球蛋白E抗体。结果：通过随机分配给大豆配方食品的8例患者（10％; 95％可信区间，4.4％-18.8％）和2例患者（2.2％; 95％可信区间，0.3％）通过挑战证实了对该配方的不良反应至7.8％）随机分配给广泛水解的配方。在IgE相关和非IgE相关的牛奶过敏中，大豆的不良反应相似（分别为11％和9％）。仅2例婴儿对大豆产生IgE，但对大豆有不良反应。大豆配方食品的不良反应在年龄较小的婴儿（<6个月）中比在年龄较大的婴儿（6至12个月）中更为常见（分别为20个中的5个vs 60个中的3个，P = 0.01）。结论：大多数婴儿对IgE相关和非IgE相关的牛奶过敏婴儿均耐受大豆配方食品。 IgE相关的大豆变态反应很少发生。对于奶牛过敏≥6个月的婴儿，大豆配方奶粉可被推荐作为首选。

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