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首页> 外文期刊>The Journal of Nutritional Biochemistry >An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice.
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An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice.

机译：早期富含鱼油的饮食可逆转小鼠后代的母体蛋白质限制，从而改变雄性后代的生化，肝脏和脂肪组织改变。

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摘要

Fetal programming is linked to adulthood metabolic and chronic diseases. We hypothesized that early fish oil (FO) intake would revert the programming responses in adult offspring. Pregnant mice were fed either standard chow (SC) or a low-protein diet (LP) throughout pregnancy/lactation. At weaning, the following groups were formed: SC and SC-FO, LP and LP-FO, which were fed SC or SC+FO, respectively. The LP offspring are predisposed to becoming fat, hypercholesterolemic and hyperglycemic. In addition, during adulthood, they become hypertensive with hepatic steatosis and have a high level of sterol regulatory element binding protein (SREBP-1). However, LP offspring that were fed an FO-enriched diet have decreased body mass (BM) gain and lower final BM. In addition, with this diet, these mice have improved lipid metabolism with a decrease in total cholesterol (TC) and triacylglyceride (TG) levels, reduced fat pad masses and reduced adipocyte size. Furthermore, these LP offspring show reduced liver structural damage of alanine aminotransferase (ALT), liver steatosis with low SREBP-1 protein expression and high peroxisome proliferator activity receptor-alpha expression, and improvement of blood pressure (BP) and tumor necrosis factor (TNF)-alpha level. Early fish oil intake has beneficial effects on the programming responses that control body fat pad, glucose and lipid metabolism, and liver and adipose tissue structure in adult programmed offspring. All rights reserved, Elsevier.
机译：胎儿编程与成年期的代谢和慢性疾病有关。我们假设早期摄入鱼油（FO）会恢复成年后代的编程反应。在整个妊娠/哺乳期，给妊娠小鼠喂食标准食物（SC）或低蛋白饮食（LP）。断奶时分为以下几组：SC和SC-FO，LP和LP-FO，分别喂食SC或SC + FO。 LP的后代容易发胖，高胆固醇血症和高血糖症。此外，在成年期，他们会因肝脂肪变性而变得高血压，并具有高水平的固醇调节元件结合蛋白（SREBP-1）。但是，饲喂富含FO的LP后代的体重（BM）增幅降低，最终BM降低。此外，通过这种饮食，这些小鼠的脂质代谢得到改善，总胆固醇（TC）和三酰甘油（TG）含量降低，脂肪垫质量降低，脂肪细胞大小降低。此外，这些LP后代显示出降低的丙氨酸转氨酶（ALT）肝结构损伤，具有低SREBP-1蛋白表达和高过氧化物酶体增殖物活性受体-α表达的肝脂肪变性以及血压（BP）和肿瘤坏死因子（TNF）的改善）-alpha级别。早期摄入鱼油对控制成年人成体后代的体内脂肪垫，葡萄糖和脂质代谢以及肝脏和脂肪组织结构的编程反应具有有益作用。保留所有权利，Elsevier。

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