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首页> 外文期刊>The Journal of Nutritional Biochemistry >Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats.
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Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats.

机译：葡萄籽原花青素对饮食诱导的肥胖大鼠局部和全身炎症的调节作用。

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摘要

Chronic low-grade inflammation in obesity is characterized by macrophage accumulation in white adipose tissue (WAT) and abnormal cytokine production. We tested the hypothesis that grape-seed procyanidin extract (PE), with known anti-inflammatory and antioxidant effects, would improve local and systemic inflammation in diet-induced obesity rats. First, we analyzed the preventive effects of procyanidins (30 mg/kg per day) on rats fed a 60% kcal fat diet for 19 weeks. Second, we induced cafeteria diet obesity for 13 weeks to investigate the corrective effects of two PE doses (25 and 50 mg/kg per day) for 10 and 30 days. In the preventive model, PE group had reduced not only body weight but also plasmatic systemic markers of inflammation tumor necrosis factor- alpha (TNF- alpha) and C-reactive protein (CRP). The PE preventive treatment significantly showed an increased adiponectin expression and decreased TNF- alpha, interleukin-6 and CRP expression in mesenteric WAT and muscle TNF- alpha. A reduced NF- kappaB activity in liver is also observed which can be related to low expression rates of hepatic inflammatory markers found in PE group. Finally, PE dietary supplementation is linked to a reduced expression of Emr1 (specific marker of macrophage F4/80), which suggests a reduced macrophage infiltration of WAT. In the corrective model, however, only the high dose of PE reduced CRP plasma levels in the short treatment without changes in plasmatic TNF- alpha. In conclusion, orally ingested PE helps preventing imbalanced obesity cytokine pattern, but its corrective effects need to be further investigated. The dietary regular intake of food or drinks containing procyanidins might help prevent low-grade inflammatory-related diseases.
机译：肥胖症的慢性低度炎症的特征在于白色脂肪组织（WAT）中的巨噬细胞蓄积和异常的细胞因子产生。我们测试了以下假设：葡萄籽原花青素提取物（PE）具有已知的抗炎和抗氧化作用，可以改善饮食诱发的肥胖大鼠的局部和全身炎症。首先，我们分析了原花青素（每天30 mg / kg）对喂食60％大卡脂肪饮食19周的大鼠的预防作用。其次，我们诱导食堂饮食肥胖症持续13周，以研究两种PE剂量（每天25和50 mg / kg）持续10天和30天的矫正效果。在预防模型中，PE组不仅减轻了体重，而且减轻了炎症肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）的血浆系统性标志物。 PE预防性治疗显着显示肠系膜WAT和肌肉TNF-α中脂联素表达增加，而TNF-α，白介素6和CRP表达降低。还观察到肝中NF-κB活性降低，这与PE组中肝炎性标志物的低表达率有关。最后，PE膳食补充剂与Emr1（巨噬细胞F4 / 80的特异性标记）表达降低有关，这表明WAT的巨噬细胞浸润减少。然而，在校正模型中，仅高剂量的PE在短期治疗中降低了CRP血浆水平，而血浆TNF-α没有变化。总之，口服摄入的PE有助于预防肥胖细胞因子的失衡模式，但其纠正效果有待进一步研究。饮食中定期摄入含有原花青素的食物或饮料可能有助于预防低度炎症相关疾病。

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