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首页> 外文期刊>The journal of obstetrics and gynaecology research >Melatonin and female reproduction
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Melatonin and female reproduction

机译：褪黑激素和女性生殖

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Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night by the pineal gland. After entering the circulation, melatonin acts as an endocrine factor and a chemical messenger of light and darkness. It regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction. It also affects the brain, immune, gastrointestinal, cardiovascular, renal, bone and endocrine functions and acts as an oncostatic and anti-aging molecule. Many of melatonin's actions are mediated through interactions with specific membrane-bound receptors expressed not only in the central nervous system, but also in peripheral tissues. Melatonin also acts through non-receptor-mediated mechanisms, for example serving as a scavenger for reactive oxygen species and reactive nitrogen species. At both physiological and pharmacological concentrations, melatonin attenuates and counteracts oxidative stress and regulates cellular metabolism. Growing scientific evidence of reproductive physiology supports the role of melatonin in human reproduction. This review was conducted to investigate the effects of melatonin on female reproduction and to summarize our findings in this field.
机译：褪黑激素（N-乙酰基-5-甲氧基色胺）在晚上的黑暗时间内由松果体分泌。进入循环后，褪黑激素充当内分泌因子和光明与黑暗的化学信使。它调节与昼夜节律和生殖有关的各种重要的中枢和外周活动。它还会影响大脑，免疫系统，胃肠道，心血管系统，肾脏，骨骼和内分泌功能，并起抑癌和抗衰老的作用。褪黑激素的许多作用是通过与不仅在中枢神经系统中而且在周围组织中表达的特定的膜结合受体相互作用而介导的。褪黑激素还通过非受体介导的机制起作用，例如用作活性氧和活性氮的清除剂。在生理和药理学浓度下，褪黑素都可以减弱和抵消氧化应激并调节细胞代谢。越来越多的生殖生理科学证据支持褪黑激素在人类生殖中的作用。进行此审查以调查褪黑激素对女性生殖的影响，并总结我们在该领域的发现。

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