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首页> 外文期刊>The Journal of toxicological sciences >Exposure to diesel exhaust during fetal period affects behavior and neurotransmitters in male offspring mice.
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Exposure to diesel exhaust during fetal period affects behavior and neurotransmitters in male offspring mice.

机译：胎儿时期暴露于柴油机废气会影响雄性后代小鼠的行为和神经递质。

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摘要

Exposure to ambient particulate matter (PM) has been associated with the onset of cardiovascular and respiratory diseases. Diesel exhaust particles (DEP) are major components of ambient PM. We first reported DEP in the central nervous system of offspring utilizing maternal inhalation to diesel exhaust (DE). In addition, we found that the effects of maternal exposure to DE reduced spontaneous motor activity. However, it is still unknown whether maternal exposure to DE affects higher order behavioral function. Therefore, the aim of the present study was to examine the effects of fetal exposure to DE on motor coordination, impulsive behavior and monoaminergic systems in various brain regions. The results of the rotating rod test showed that DE-exposed mice displayed decreased time on the rota rod compared to control mice. However, no changes were detected between the two groups in the hanging test. Furthermore, the cliff avoidance test revealed that DE-exposed mice spent more time in the corner and fell off an inverted glass beaker compared to control mice. High performance liquid chromatography analysis revealed that noradrenaline turnover in the cerebellum was decreased by prenatal exposure to DE, and was significantly increased in the hypothalamus. Dopamine and serotonin levels in various brain regions were also changed by prenatal exposure to DE. Our study found that prenatal exposure to DE alters motor coordination, impulsive behavior and related monoamine levels. Therefore, the present study underscores the role of behavioral changes related to monoamine in response to maternal inhalation of DE.
机译：暴露于环境颗粒物（PM）与心血管疾病和呼吸道疾病有关。柴油机废气颗粒（DEP）是环境PM的主要成分。我们首先报道了母体吸入柴油机废气（DE）后代中枢神经系统中的DEP。此外，我们发现孕妇暴露于DE的影响降低了自发运动活动。然而，母体暴露于DE是否会影响高阶行为功能仍是未知的。因此，本研究的目的是检验胎儿暴露于DE对大脑各个区域的运动协调，冲动行为和单胺能系统的影响。旋转棒测试的结果表明，与对照小鼠相比，暴露于DE的小鼠在旋转棒上显示的时间减少。但是，在悬挂测试中两组之间均未发现变化。此外，避免悬崖试验显示，与对照小鼠相比，暴露于DE的小鼠在角上花费的时间更长，并且掉下了倒置的玻璃烧杯。高效液相色谱分析显示，产前暴露于DE会降低小脑中的去甲肾上腺素转换，在下丘脑中会显着增加。产前暴露于DE也会改变大脑各个区域的多巴胺和血清素水平。我们的研究发现，产前暴露于DE会改变运动协调性，冲动行为和相关的单胺水平。因此，本研究强调了与母体吸入DE有关的单胺相关行为改变的作用。

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