The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

LiY.; BaeH.-I.; KimH.-S.; KangM.-S.; JungW.-H.; KimK.-H.; SongS.-W.; KangB.-H.

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The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

机译：盲肠嗜酸性粒细胞浸润的光谱及其与多发性肉芽肿和动脉炎的其他疾病的关系

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Spontaneous multiple granulomas were present in the animal under the SPF condition and without chemical treatment, in a 19-week-old male Sprague-Dawley control-group rat. Here we describe multiple granulomas and prominent diffuse infiltration by eosinophils in the cecal submucosa, and arteritis in the mesenteric arteries. The multiple granulomas were characterized by central eosinophilic degeneration or necrosis, prominent eosinophils, many multi-nucleated giant cells and abundant fibroblasts. They were restricted to the cecal submucosa. The mesenteric arteritis consisted of fibrinoid necrosis of the intima and media, intense inflammatory cell infiltration and fibrosis in the arterial wall. An affected artery in the cecum was continuous with the mesenteric artery. The foregoing tissue changes in this rat correlate with the high absolute blood eosinophil count found in this animal.

机译：一只19周大的雄性Sprague-Dawley对照组大鼠在SPF条件下未经化学处理就存在自发性多肉芽肿。在这里，我们描述了多发性肉芽肿和盲肠粘膜下嗜酸性粒细胞显着的弥漫性浸润，以及肠系膜动脉的动脉炎。多发性肉芽肿的特征是中央嗜酸性粒细胞变性或坏死，嗜酸性粒细胞突出，许多多核巨细胞和丰富的成纤维细胞。他们仅限于盲肠粘膜下层。肠系膜动脉炎包括内膜和中层纤维蛋白样坏死，强烈的炎性细胞浸润和动脉壁纤维化。盲肠中的患动脉与肠系膜动脉连续。该大鼠的前述组织变化与在该动物中发现的较高的绝对血液嗜酸性粒细胞计数相关。

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《The Journal of toxicological sciences》 |2014年第2期|共7页
作者
LiY.; BaeH.-I.; KimH.-S.; KangM.-S.; JungW.-H.; KimK.-H.; SongS.-W.; KangB.-H.;
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正文语种 eng
中图分类药学;
关键词
Arteritis; Cecum; Eosinophilic infiltration; Multiple granulomas;

机译：动脉炎;盲肠;嗜酸性浸润;多肉芽肿;

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1. The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat [J] . LiY., BaeH.-I., KimH.-S., The Journal of toxicological sciences . 2014,第2期

机译：盲肠嗜酸性粒细胞浸润的光谱及其与多发性肉芽肿和动脉炎的其他疾病的关系
2. Increase of mast cells may be associated with infiltration of eosinophils and proliferation of microvessels in gastric eosinophilic granuloma. [J] . Li X, Gao ZJ, Cao JW, Journal of gastroenterology and hepatology . 2007,第1期

机译：肥大细胞增加可能与嗜酸性粒细胞肉芽肿中嗜酸性粒细胞浸润和微血管增生有关。
3. Eosinophilic granuloma of the clivus: case report, follow-up of two previously reported cases, and review of the literature on cranial base eosinophilic granuloma. [J] . Brisman JL, Feldstein NA, Tarbell NJ, Neurosurgery . 1997,第1期

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机译：患有C1和幼儿肺浸润的脊柱的嗜酸性粒细胞粒细胞粒细胞粒细胞粒细胞瘤 - 介绍了两种案例，随访10年，包括对文献的审查

The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

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