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首页> 外文期刊>The Lancet >Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study.
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Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study.

机译：老年妇女使用血管紧张素转换酶抑制剂与肌肉力量和身体功能之间的关系：一项观察性研究。

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BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors prevent decline in physical function in patients with congestive heart failure (CHF). We aimed to see whether ACE inhibitors also prevent reduction in physical performance and in muscle strength in older women who do not have CHF. METHODS: We assessed 3-year rates of decline in both knee extensor muscle strength and walking speed in 641 women with hypertension who had participated in the Women's Health and Aging Study. Women were stratified into four groups according to type and duration of antihypertensive drug treatment. 61 had used ACE inhibitors continuously, 133 intermittently, 146 never, and 301 had used other hypertensive drugs either continuously or intermittently. FINDINGS: Participants who had taken ACE inhibitors continuously had a lower mean 3-year decline in muscle strength of -1.0 kg (SE 1.1) compared with -3.7 (0.5) kg in continuous/intermittent users of other antihypertensive drugs (p=0.016) and with -3.9 kg in those who had never used antihypertensives (p=0.026). Muscle strength fell by 3.0 kg in 3 years in both continuous and intermittent users of ACE inhibitors (p=0.096). Mean 3-year decline in walking speed in continuous ACE inhibitor users was -1.7 cm/s compared with -13.6 cm/s in intermittent users of ACE inhibitors (p=0.015), -15.7 cm/s in continuous/intermittent users of other antihypertensive drugs (p=0.002), and -17.9 cm/s in never users of antihypertensive drugs (p=0.001). INTERPRETATION: ACE inhibitor treatment may halt or slow decline in muscle strength in elderly women with hypertension and without CHF.
机译：背景：血管紧张素转换酶（ACE）抑制剂可预防充血性心力衰竭（CHF）患者的身体功能下降。我们旨在观察ACE抑制剂是否还可以防止没有CHF的老年女性的身体机能和肌肉力量下降。方法：我们评估了参加“妇女健康与衰老研究”的641名高血压妇女的膝伸肌力量和行走速度的3年下降率。根据抗高血压药物治疗的类型和持续时间，将女性分为四类。 61例连续使用ACE抑制剂，间断使用133种，从未使用过146种，301例连续或间断使用其他高血压药物。结果：连续服用ACE抑制剂的参与者的3年平均肌肉力量下降幅度较小，为-1.0 kg（SE 1.1），而连续/间歇使用其他降压药的患者的肌肉平均下降幅度为-3.7（0.5）kg（p = 0.016）从未使用过降压药的患者体重为-3.9千克（p = 0.026）。在连续和间歇使用ACE抑制剂的情况下，肌肉强度在3年内下降了3.0 kg（p = 0.096）。连续使用ACE抑制剂的使用者平均3年步行速度下降为-1.7 cm / s，相比之下，使用ACE抑制剂的间歇性使用者为-13.6 cm / s（p = 0.015），其他使用连续/间歇性使用者的-15.7 cm / s服用降压药（p = 0.002），从不使用降压药的患者为-17.9 cm / s（p = 0.001）。解释：ACE抑制剂治疗可能会在患有高血压但没有CHF的老年妇女中停止或减慢肌肉力量。

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