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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Adipocytokines, fat distribution, and insulin resistance in elderly men and women.
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Adipocytokines, fat distribution, and insulin resistance in elderly men and women.

机译：老年男性和女性的脂肪细胞因子，脂肪分布和胰岛素抵抗。

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BACKGROUND: The aim of this study was to evaluate the relation between adiponectin and leptin, fat distribution, and insulin resistance in elderly men and women. METHODS: 68 elderly participants (28 men and 40 women) aged 66-77 years, with body mass index (BMI) ranging from 19.83 to 37.18 kg/m2, participated in the study. In all participants, we evaluated BMI, waist and hip circumferences, sagittal abdominal diameter (SAD), fat mass (FM) by dual energy X-ray absorptiometry, fasting and 2-hour glucose, insulin, homeostasis model assessment of insulin resistance (HOMA), leptin, and adiponectin. RESULTS: Elderly women had significantly higher circulating levels of adiponectin and leptin compared to men even after adjusting for age, FM, or waist circumference. In men and women, leptin was positively associated, whereas adiponectin was negatively associated, with BMI, indices of body fat distribution, as well as FM and FM%. Both fasting insulin and HOMA showed significant positive correlation with leptin and negative correlation with adiponectin in both sexes. In a step-wise multiple regression model with HOMA as the dependent variable and age, gender, waist circumference, FM, leptin, and adiponectin as independent variables, waist entered the regression first, explaining 19.7% of HOMA variance, leptin was second, and adiponectin was third, explaining each one an additional 10% of variance. In a multiple linear regression analysis, leptin and adiponectin alone explained up to 38% of HOMA variance. CONCLUSION: Leptin and adiponectin together seem to be strictly related to insulin resistance in elderly people, independently of body fat and body fat distribution.
机译：背景：本研究的目的是评估老年男女脂联素与瘦素，脂肪分布和胰岛素抵抗之间的关系。方法：68名年龄在66-77岁之间，体重指数（BMI）为19.83至37.18 kg / m2的老年参与者（28名男性和40名女性）参加了研究。在所有参与者中，我们通过双能X射线骨密度仪，禁食和2小时葡萄糖，胰岛素，稳态胰岛素抵抗模型评估（HOMA）评估了BMI，腰围和臀围，矢状腹径（SAD），脂肪量（FM） ），瘦素和脂联素。结果：即使调整了年龄，FM或腰围，老年女性的脂联素和瘦素循环水平也明显高于男性。在男性和女性中，瘦素与BMI，身体脂肪分布指数以及FM和FM％呈正相关，而脂联素则呈负相关。空腹胰岛素和HOMA均与瘦素呈显着正相关，与脂联素呈负相关。在以HOMA为因变量，以年龄，性别，腰围，FM，瘦素和脂联素为自变量的逐步多元回归模型中，腰部首先进入回归，解释了19.7％的HOMA方差，瘦素次之，脂联素位居第三，解释了每一个另外的10％的差异。在多元线性回归分析中，仅瘦素和脂联素可解释高达38％的HOMA方差。结论：瘦素和脂联素似乎与老年人的胰岛素抵抗密切相关，而与体脂和体脂分布无关。

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