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首页> 外文期刊>Therapeutic advances in respiratory disease. >Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: A pilot study
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Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: A pilot study

机译：光电体积描记法评估噻托溴铵和福莫特罗对安静呼吸模式的影响：一项初步研究

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Introduction: Chronic obstructive pulmonary disease (COPD) is a disease characterized by an airflow limitation that is not fully reversible. β 2-agonists and anticholinergics represent the most effective therapeutic options. Optoelectronic plethysmography (OEP) is a novel technology, which provides noninvasive steady-state measurements of chest wall kinematics, together with the assessment of the relative contribution of all different thoracic and abdominal compartments to tidal volume.Objectives: The aim of this pilot study was to investigate the changes in quiet breathing due to different long-acting bronchodilators (namely, formoterol and tiotropium) administered to COPD patients of different severity.Methods: Eight moderate-to-severe COPD patients were studied according to a randomized crossover design. All subjects received both the long-acting bronchodilators: formoterol (long-acting β 2-agonist, 24 μg) and tiotropium (long-acting anticholinergic bronchodilator, 18 μg). The effect of bronchodilators on quiet breathing was evaluated by means of OEP at base conditions, and 2 and 7 hours after inhalation.Results: Both bronchodilators caused changes in the quiet breathing pattern in COPD patients that had previously reported only negligible changes in FEV 1 (ΔFEV 1 = 2.6% after salbutamol). The main changes were observed in increased ventilation per minute, inspiratory and expiratory flow, and decreased breath-by-breath variability. Formoterol induced its main effects during the first 2 hours after inhalation, while tiotropium caused improvements between 2 and 7 hours.Conclusion: Even though a greater cohort of COPD patients is needed in order to confirm the present results, this pilot study reports a novel piece of evidence concerning the effects of bronchodilators on quiet breathing pattern in severe and very severe COPD patients.
机译：简介：慢性阻塞性肺疾病（COPD）是一种气流受限，不能完全逆转的疾病。 β2受体激动剂和抗胆碱能药是最有效的治疗选择。光电体积描记法（OEP）是一项新颖的技术，可对胸壁运动学进行无创稳态测量，并评估所有不同胸腔和腹腔对潮气量的相对贡献。目的：这项初步研究的目的是研究不同严重程度的COPD患者使用不同的长效支气管扩张药（即福莫特罗和噻托溴铵）导致的安静呼吸变化。方法：根据随机交叉设计研究了八名中度至重度COPD患者。所有受试者均接受了长效支气管扩张剂：福莫特罗（长效β2受体激动剂，24μg）和噻托溴铵（长效抗胆碱能支气管扩张剂，18μg）。在基本情况下，吸入后2小时和7小时，通过OEP评估支气管扩张剂对安静呼吸的影响。结果：两种支气管扩张剂均导致COPD患者的安静呼吸模式发生变化，这些患者先前报告的FEV 1仅可忽略不计（沙丁胺醇后ΔFEV1 = 2.6％）。观察到的主要变化是每分钟通气量增加，吸气和呼气流量增加，逐呼吸变化减少。福莫特罗在吸入后的前2小时内诱导了其主要作用，而噻托溴铵在2至7小时内引起了改善。结论：尽管需要更多的COPD患者队列以证实目前的结果，但该初步研究报告了一项新颖的研究严重和非常严重的COPD患者中支气管扩张剂对安静呼吸模式影响的证据。

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