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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Seroprevalence of hepatitis B in two period birth cohorts of Bolivian children: effect of universal vaccination.
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Seroprevalence of hepatitis B in two period birth cohorts of Bolivian children: effect of universal vaccination.

机译：玻利维亚儿童的两个定期出生队列中的乙型肝炎血清流行：全民接种疫苗的效果。

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摘要

Since 2000 universal routine immunization against the hepatitis B virus (HBV) was implemented in Bolivia. This study aimed to assess the seroprevalence of markers against HBV in two different birth cohorts (pre-universal vaccine cohort and post-universal vaccine cohort) from Cochabamba, Bolivia.We performed a school-based seroepidemiological survey (n = 424) of HBV in 2010 in the Cochabamba region. An ELISA test was used to measure antibodies to the hepatitis B surface antigen (anti-HBs IgG) and to the hepatitis B core antigen (anti-HBc IgG).The prevalence of anti-HBs IgG in the pre-universal vaccine cohort was 5.8% (95% CI: 3.3-8.3%); it was higher in boys (9.1%), and those living in suburbs (9.7%). The anti-HBs IgG prevalence among post-universal vaccine cohort was 37.9% (95% CI: 28.5-48.1%), and was higher in children who spoke Quechua at home (51.0%), those living in suburbs (53.9%), and those born in 2005 (72.7%). Neither cohort showed differences relating to parental education. The prevalence of anti-HBc IgG was 1.1% among post-universal vaccine cohort and 1.2% among pre-universal vaccine cohort (p > 0.05).This study identified a persistent low seroprevalence of hepatitis B infection in spite of a decade of universal immunization, and low long-term humoral immunity against HBV infection in vaccinated children in Cochabamba.?
机译：自2000年以来，玻利维亚开始实施针对乙型肝炎病毒（HBV）的常规常规免疫。这项研究旨在评估来自玻利维亚科恰班巴的两个不同出生队列（通用疫苗队列和通用疫苗队列）中针对HBV的血清学阳性率。 2010年在Cochabamba地区。 ELISA试验用于测量针对乙型肝炎表面抗原（抗HBs IgG）和针对乙型肝炎核心抗原（抗HBc IgG）的抗体。普及前疫苗队列中抗HBs IgG的患病率为5.8 ％（95％CI：3.3-8.3％）;男生（9.1％）和郊区的人（9.7％）更高。普及疫苗后队列中的抗HBs IgG患病率为37.9％（95％CI：28.5-48.1％），在家中讲盖丘亚语的儿童（51.0％），郊区说魁北克的儿童（53.9％），以及2005年出生的人（72.7％）。两组均未显示与父母教育有关的差异。普遍免疫后十年，抗HBc IgG的普及率在普通疫苗接种组中为1.1％，在普通疫苗接种组中为1.2％（p> 0.05）。 ，并且在科恰班巴接种疫苗的儿童对HBV感染的长期体液免疫力低。

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